Characterization of marine-derived halogenated indoles as ligands of the aryl hydrocarbon receptor.

Jessie King, Victoria H Woolner, Robert A Keyzers, Rhonda J Rosengren

Open access · goldAbstract read

In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.4field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Antifungal Activities of Multi-Halogenated Indoles Against Drug-ResistantInternational journal of molecular sciences · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jessie KingDepartment of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.

Victoria H WoolnerSchool of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.

Robert A KeyzersSchool of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.

Rhonda J RosengrenDepartment of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.

University of Otago · NZVictoria University of Wellington · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor thought to mediate a number of physiological roles in the body, is becoming a target of interest for the development of new therapeutics. However, previous research has demonstrated that the downstream effects of AhR ligands cannot be predicted based simply on whether a ligand acts as an agonist or antagonist and the persistence of AhR signaling is thought to be a key determining feature. The current study investigated the AhR activity of four halogenated indoles isolated from the New Zealand red alga,

Indexed as

4DBDCI, 4,7-dibromo-2,3-dichloroindole6DBDCI, 6,7-dibromo-2,3-dichloroindoleAhR, aryl hydrocarbon receptorARNT, AhR nuclear translocator proteinAryl hydrocarbon receptorBCA, bicinchoninic acidBDCII, 7-bromo-2,3-dichloro-6-iodoindoleCYP1A1, cytochrome P4501A1EROD, ethoxyresorufin-O-deethylaseFICZ, 6-formylindolo[3,2b]carbazoleHalogenated indolesRhodophyllis membranaceaSRB, sulforhodamine BTBCI, 2,6,7-tribromo-3-chloroindoleTCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinXRE, xenobiotic response element

Identifiers

PMID36518459

DOI10.1016/j.toxrep.2022.05.016

PMCPMC9742904

OpenAlexW4281553459

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.