Evidence map›Paper›PMID 36518457›Full record

ArticleToxicology reports2022

Acute toxicity potential and impact on periodontal and periapical tissue of Pulp Out: A paste contained jatropha, sidaguri, and melittin.

Maria Tanumihardja, A M Windha, N Musfirah, G K Punggawa, Andi Fatima, A H M Nur Fadhila, Esfandiary, Nurhayaty Natsir, Husni Cangara, Lukman Muslimin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maria TanumihardjaDepartment of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
A M WindhaUnder Graduate Programme of Department of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
N MusfirahUnder Graduate Programme of Department of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
G K PunggawaPost Graduate Specialist Programme of Department of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Andi FatimaPost Graduate Specialist Programme of Department of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
A H M Nur FadhilaPost Graduate Specialist Programme of Department of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
EsfandiaryPost Graduate Specialist Programme of Department of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Nurhayaty NatsirDepartment of Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Husni CangaraDepartment of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
Lukman MusliminSekolah Tinggi Ilmu Farmasi Makassar, Perintis Kemerdekaan KM 13.7, Makassar, South Sulawesi, Indonesia.
Hasanuddin University · IDUniversitas Patria Artha · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulp Out, paste-contained jatropha sap, sidaguri roots, and melittin, has been studied to have potency used as an herbal-based devitalizing agent. Prior to clinical application, the toxicity of Pulp Out should be evaluated as it might leak from the cavity unintentionally and get into the digestive systems, which can cause either local or systemic effects. The present study aimed to evaluate the impact of Pulp Out application on periodontal and periapical tissue as well as acute toxicity in Wistar rats. The paste was inserted into the periapical tissue. After 7 days, the periapical tissue was isolated for histopathological evaluation. Pulp Out in an oral suspension of 50, 500 and 2500 mg/kg BW was administered. Autonomic nerve signs were observed intensively every 4 h as well as water and food consumption for 14 days. Biochemical, hematologic parameters and specific organs were evaluated. Therefore, considering the inflammatory lymphocyte cells, osteoblasts, and osteoclasts, Pulp Out is not toxic. The acute toxicity study revealed no treatment-related death was observed, indicating that LD

Indexed as

Acute toxicityBiochemical parameterHistopathological evaluation

Identifiers

PMID36518457
PMCPMC9742943
OpenAlexW4296182657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.