Evidence map›Paper›PMID 36518435›Full record

ArticleToxicology reports2022

Acute oral toxicity of damnacanthal and its anticancer activity against colorectal tumorigenesis.

Warunya Woradulayapinij, Apipu Pothiluk, Thararat Nualsanit, Thunyatorn Yimsoo, Werayut Yingmema, Pleumchitt Rojanapanthu, Yukyung Hong, Seung Joon Baek, Worapapar Treesuppharat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Warunya WoradulayapinijThammasat University Research Unit in Mechanisms of Drug Action and Molecular Imaging, Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Apipu PothilukThammasat University Research Unit in Mechanisms of Drug Action and Molecular Imaging, Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Thararat NualsanitChulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Thunyatorn YimsooLaboratory Animal Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Werayut YingmemaLaboratory Animal Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Pleumchitt RojanapanthuDrug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Yukyung HongLaboratory of Signal Transduction, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea.
Seung Joon BaekLaboratory of Signal Transduction, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea.
Worapapar TreesuppharatThammasat University Research Unit in Mechanisms of Drug Action and Molecular Imaging, Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Thammasat University · THSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Damnacanthal is an anthraquinone, extracted, and purified from the root of

Indexed as

5-FU, 5-FluorouracilAcute oral toxicityALT, Alanine aminotransferaseAnticancer activityAST, Aspartate aminotransferaseBSA, Bovine serum albuminBUN, Blood urea nitrogenColorectal tumorigenesisD20, Damnacanthal at 20 mg/kgD40, Damnacanthal at 40 mg/kgDamnacanthalDMSO, Dimethyl sulfoxideDPBS, Dulbecco’s phosphate buffered salineF20, 5-Fluorouracil at 20 mg/kgFBS, Fetal bovine serumFTIR, Fourier transform infrared spectroscopyIC50, Half-maximal inhibitory concentrationLD50, Median lethal doseMS, Mass spectrometryMTT, 3-(4,5-Dimethythiazol-2-yl)− 2,5-diphenyltetrazolium bromideNC, Negative controlNMR, Nuclear magnetic resonance spectroscopyPMSF, Phenylmethanesulfonyl fluorideTBST, Tris-buffered saline containing 0.05 % Tween 20TLC, Thin layer chromatographyVLC, Vacuum liquid chromatographic method

Identifiers

PMID36518435
PMCPMC9742955
OpenAlexW4307765510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.