ArticleToxicology reports2022
Effect of e-cigarette aerosol on gingival mucosa structure and proinflammatory cytokine response.
Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Longitudinal comparison of peri-implant clinical and radiographic parameters between e-cigarette users and conventional cigarette smokers.BMC oral health · 2026Article
- Inflammatory Biomarker Profiles in Gingival Crevicular Fluid of Electronic Cigarette Users: A Cross-Sectional Study.Dentistry journal · 2026Article
- Impact of e-cigarette vaping on the immune system across the body.Physiological reviews · 2026Review
- Vape flavoring chemicals and oral fibroblast viability.Anatomy & cell biology · 2026Review
- E-cigarettes and periodontal health: current evidence and research gaps.Brazilian oral research · 2026Review
- Article
- Article
- E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025Review
- Effects of Short-term Electronic(e)-Cigarette Aerosol Exposure in the Mouse Larynx.The Laryngoscope · 2024Article
- E-cigarette aerosol exposure drives extracellular matrix gene dysregulation and collagen remodeling in gingival fibroblasts: AnJournal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the effect of multiple exposures to electronic cigarettes on human oral mucosa structure and proinflammatory cytokine secretion. A 3D air-liquid interface human gingival mucosa was produced and exposed 10 min twice a day for 2 and 4 days for a total of 4 or 8 exposure times to e-cigarette aerosol. The vaped e-liquid contained 18 mg/ml of nicotine. Results show that 4 and 8 exposures to the e-cigarettes with and without nicotine-induced structural tissue damage, decreased Laminin and type IV collagen production but increased the secretions of several metalloproteinases (MMPs), and lactate dehydrogenase (LDH). The e-cigarette reduced the number of proliferative epithelial cells, as ascertained by the low number of Ki-67
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.