Evidence map›Paper›PMID 36518403›Full record

ArticleToxicology reports2022

Postmortem sampling time effect on toxicity biomarkers in rats exposed to an acute lethal methomyl dose.

Shreen D Nusair, Mohammad Ananbeh, Aref Zayed, Mohammad I Ahmad, Nidal A Qinna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shreen D NusairDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Mohammad AnanbehDepartment of Forensic Medicine Toxicology and Forensic Sciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Aref ZayedDepartment of Medicinal Chemistry and Phramacognosy, Jordan University of Science and Technology, Irbid, Jordan.
Mohammad I AhmadUniversity of Petra Pharmaceutical Center (UPPC), Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan.
Nidal A QinnaUniversity of Petra Pharmaceutical Center (UPPC), Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan.
Jordan University of Science and Technology · JOPetra University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulations often are imposing long postmortem times before autopsy leading to certain toxicity-unrelated changes in biomarkers, which in turn may affect the reliability of toxicity evaluation during forensic investigations. Since methomyl pesticide shows significant toxicity and is frequently encountered in poisoning cases, the current study evaluated different parameters in methomyl intoxicated rats at three different postmortem intervals (Hour 0, Hour 3 and Hour 6). Eighteen adult Sprague Dawley rats were poisoned with methomyl to simulate actual methomyl poisoning cases. The time of death was assigned as Hour 0. The animals were divided into 3 groups (

Indexed as

Acetylcholinesterase, Sampling timeAChE, Acetylcholinesterase activityACUC, Animal Care CommitteeANOVA, Analysis of Variancebwt, Body weightChE, CholinesteraseESI, Electrospray ionizationGC, Gas chromatographyIS, Internal standardJCIA, Joint Commission International AccreditationJFDA, Jordan Food and Drug AdministrationLC, Liquid chromatographyLC-MS/MSLC-MS/MS, Liquid Chromatography-Tandem Mass SpectrometryLOD, Limit of detectionLOQ, Limit of quantitationMethomylMRM, Multiple reaction monitoringM ± SD, Mean ± standard deviationm/z, Mass-to-charge ratioPBS, Phosphate-Buffered SalinePesticidesPRC, Pharmaceutical Research CenterSPEToxicityUPPC, University of Petra Pharmaceutical CenterUS EPA, United States Environmental Protection Agency

Identifiers

PMID36518403
PMCPMC9742944
OpenAlexW4292868480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.