Evidence map›Paper›PMID 36518376›Full record

ArticleToxicology reports2022

Human health risk assessment of heavy metals in drinking water sources in three senatorial districts of Anambra State, Nigeria.

Ugwu Chidiebere Emmanuel, Maduka Ignatius Chukwudi, Suru Stephen Monday, Anakwuo Ikechukwu Anthony

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.

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  19. Study of the Trace Element Composition of Drinking Water in Almaty City and Human Health Risk Assessment.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ugwu Chidiebere EmmanuelDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Maduka Ignatius ChukwudiDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Suru Stephen MondayDepartment of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Anakwuo Ikechukwu AnthonyDepartment of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Nnamdi Azikiwe University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct exposure to heavy metals (HMs) in drinking water beyond the allowable tolerable limit can adversely affect human health. The study evaluated the hazards (cancer and non-cancer) of HMs in drinking water for both children and adults based on hazard quotients (HQ) derived from the concentration of HMs in drinking water in Anambra State, Nigeria. Eighty-one water samples were collected from 5 water sources (borehole, well, sachet water, harvested rain, and stream water) in 3 districts of Anambra State, and their concentrations of selected HMs [lead (Pb), cadmium (Cd), and mercury (Hg)] were analyzed by Atomic Absorption Spectrometry (AAS). The health risks were assessed based on the concentrations of HMs in the water samples ingested orally. The concentrations of the HMs were higher than the permissible limits recommended by international agencies. The chronic daily intake (CDI) indices in the studied areas were highest for Cd. The CDI indices in the borehole, well, sachet water and, stream water samples were Cd>Hg>Pb for both populations. The CDI was higher in children compared to adults exposed to the same water sources. The hazard quotient (HQ) indices for HMs in the various water sources were in the order Cd>Pb>Hg for both populations. The hazard index (HI) of Pb was highest in rain water while that of Hg and Cd were highest in stream water for both adults and children. The incremental life cancer risk (ILCR) in the studied areas showed a higher risk for children than adults. Cadmium was a major risk factor and children at greater cancer risk than adults. Generally, the HQ and ILCR were greater than international standards with values for children higher than adults. The contribution of Cd towards HI and ILCR in all cases was significant. This study showed the concentrations of the HMs in drinking water sources, and their attendant HQ and ILCR. These values were higher than the permissible limits set by international agencies. The results demonstrated enormously worrisome risks for children than adults.

Indexed as

Anambra StateCancerHazard riskHeavy metalsWater

Identifiers

PMID36518376
PMCPMC9742819
OpenAlexW4224035754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.