Evidence map›Paper›PMID 36518375›Full record

ArticleToxicology reports2022

Safety evaluation of dried L-tryptophan fermentation product in Sprague-Dawley rats.

Soo Min Ko, Ji-Eun Park, Sang-Ho Kim, Myeong Kyu Park, Ja Kyung Seol, In Kyung Heo, Yong-Uk Shin, So-Young Kim, Yang Hee Kim, Woo-Chan Son

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Soo Min KoDepartment of Medical Science, Asan Medical Institute of Convergence Science and technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Ji-Eun ParkCJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Sang-Ho KimKorea Testing and Research Institute, Hwasun-gun, Jeollanam-do 58141, Republic of Korea.
Myeong Kyu ParkKorea Testing and Research Institute, Hwasun-gun, Jeollanam-do 58141, Republic of Korea.
Ja Kyung SeolKorea Testing and Research Institute, Hwasun-gun, Jeollanam-do 58141, Republic of Korea.
In Kyung HeoCJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Yong-Uk ShinCJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
So-Young KimCJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Yang Hee KimCJ CheilJedang, Suwon-si, Gyeonggi-do 16495, Republic of Korea.
Woo-Chan SonDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
CJ CheilJedang (South Korea) · KRKorea Testing & Research Institute · KRAsan Medical Center · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The subchronic toxicity of oral L-tryptophan produced by fermentation with metabolically engineered

Indexed as

BUN, blood urea nitrogenDRF, dose range-findingDried L-tryptophan fermentation productEMS, eosinophilia-myalgia syndromeEosinophilia-myalgia syndromeFFPE, formalin-fixed paraffin-embeddedGHS, globally harmonized systemGLP, good laboratory practiceHED, human equivalent doseIHC, immunohistochemistryMetabolically engineered Corynebacterium glutamicumNOAEL, no observed adverse effect levelOECD, Organization for Economic Cooperation and DevelopmentOral administrationpAb, polyclonal antibodySD, Sprague-DawleySubchronic toxicityWBC, white blood cell

Identifiers

PMID36518375
PMCPMC9742870
OpenAlexW4229447722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.