Evidence map›Paper›PMID 36518374›Full record

ArticleToxicology reports2022

Effects of electronic cigarette flavorants on human platelet aggregation ex vivo.

Andre Richardson, Tatiana Krivokhizhina, Pawel Lorkiewicz, Stanley D'Souza, Aruni Bhatnagar, Sanjay Srivastava, Daniel J Conklin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andre RichardsonDepartment of Pharmacology and Toxicology, School of Medicine, University of Louisville, USA.
Tatiana KrivokhizhinaChristina Lee Brown Envirome Institute, University of Louisville, USA.
Pawel LorkiewiczChristina Lee Brown Envirome Institute, University of Louisville, USA.
Stanley D'SouzaDepartment of Physiology, School of Medicine, University of Louisville, USA.
Aruni BhatnagarChristina Lee Brown Envirome Institute, University of Louisville, USA.
Sanjay SrivastavaChristina Lee Brown Envirome Institute, University of Louisville, USA.
Daniel J ConklinChristina Lee Brown Envirome Institute, University of Louisville, USA.
University of Louisville · US

Funding

ConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
Cardiovascular Toxicity of Tobacco Products and ConstituentsR01HL122676 · NHLBI · UNIVERSITY OF LOUISVILLE · PI CONKLIN, DANIEL JOSEPH · 2015 to 2019
$3.7M
NHLBI NIH HHS R01 HL122676NHLBI NIH HHS U54 HL120163NIEHS NIH HHS P30 ES030283
6 · The paper itself

Abstract

Because little is known about the effects of individual flavorants in electronic cigarette (e-cig) fluids on human platelet aggregation, we tested for the direct effects of 15 common e-cig flavorants on adenosine diphosphate (ADP)-induced human platelet aggregation

Indexed as

AA, arachidonic acidADP, adenosine diphosphateCVD, cardiovascular diseaseE-cig, electronic cigaretteElectronic cigarettesElectronic nicotine delivery systemsENDS,, electronic nicotine delivery systemsEugenolFlavorantsGRAS, generally regarded as safeNO, nitric oxideP1,, phase 1 aggregationP2,, phase 2 aggregationPAF, platelet activating factorPG, propylene glycolPPP,, platelet-poor plasmaPRP,, platelet-rich plasmaROS, reactive oxygen speciesThrombosisTobaccoTxA2, thromboxane A2VG, vegetable glycerol

Identifiers

PMID36518374
PMCPMC9742839
OpenAlexW4224438742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.