Evidence map›Paper›PMID 36518274›Full record

ArticlePeerJ2022

Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice.

Zongzhuang Wen, Haixia Zhu, Bin Wu, Aizhen Zhang, Hongxiang Wang, Yin Cheng, Hui Zhao, Jianyuan Li, Min Liu, Jiangang Gao

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zongzhuang Wen *Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, China.
Haixia Zhu *School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, China.
Bin WuDepartment of Reproductive Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Aizhen ZhangDepartment of Reproductive Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Hongxiang WangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, China.
Yin ChengSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, China.
Hui ZhaoMedical Science and Technology Innovation Center, Shandong First Medical University, Jinan, China.
Jianyuan LiKey Laboratory of Male Reproductive Health, Institute of Science and Technology, National Health Commission, Beijing, China.
Min LiuMedical Science and Technology Innovation Center, Shandong First Medical University, Jinan, China.
Jiangang GaoMedical Science and Technology Innovation Center, Shandong First Medical University, Jinan, China.
Shandong University · CNShandong First Medical University · CNJinan Central Hospital · CNNational Health and Family Planning Commission · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermatogenesis and sperm maturation are complex and highly ordered biological processes. Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability. Cathepsin B (CTSB) is involved in the regulation of a variety of pathological processes. In the present study, we found that CTSB was abundantly expressed in the male reproductive system, however, the specific role of CTSB in regulating spermatogenesis and sperm maturation remained elusive. Hence, we generated

Indexed as

Cathepsin BSpermatogenesisAnimalsApoptosisMaleMiceSemenSperm MaturationCathepsin BCRISPR/Cas9CTSBSpermatogenesisSperm maturation

Identifiers

PMID36518274
PMCPMC9744162
OpenAlexW4311101872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.