ArticleFrontiers in endocrinology2022
Albinism in the largest extant amphibian: A metabolic, endocrine, or immune problem?
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Coloration Characteristics of the Chinese Giant Salamander (Animals : an open access journal from MDPI · 2026Article
- Article
- Knocking out genes to reveal drivers of natural selection on phenotypic traits: a study of the fitness consequences of albinism.Proceedings. Biological sciences · 2025Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
Background: Pigment regression is an intriguing phenomenon that can be caused by disorders in melanin metabolism or endocrine regulation, or by autoimmune disorders. Albino animals serve as excellent models for the study of the genetic determination of morphology, particularly the evolution of and molecular mechanisms underlying chromatophore-related diseases in animals and humans. Material and Methods: The artificial culture of Results: The results indicated decreased transcription of genes of melanin synthesis. Interestingly, MHC I isotypes and immune-related pathways accounted for the primary transcriptional differences between groups, suggesting that the albino phenotype represents a systematic immune problem to a far greater extent than a pigmentation defect. Albino individuals exhibited shifted transcription of MHC I isotypes, and the albino-specific isotype was characterized by increased charges and decreased space in the antigen- binding pocket, implying a drastic change in antigen specificity and a potential risk of autoimmune disorders. Conclusion: These results suggest an association between the albino phenotype and MHC I variants in
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