Evidence map›Paper›PMID 36518134›Full record

ArticleBioinformation2022

Molecular docking analysis of metformin analogues with GSK-3β.

Ponnu Lakshmi Rajagopal, Vidhya Rekha Umapathy, Sandhya P, Fathima Jh, Ramajayam Govindan, Chella Perumal Palanisamy, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ponnu Lakshmi RajagopalCentral Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, India.
Vidhya Rekha UmapathyDepartment of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India.
Sandhya PDepartment of Biochemistry, Allied Health science, Dr. M.G.R Educational and Research Institute, Chennai India.
Fathima JhDepartment of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India.
Ramajayam GovindanMulti Disciplinary Research Unit, Madurai Medical College, TamilNadu, India.
Chella Perumal PalanisamyState Key Laboratory of Bio-based Materials and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
Vishnu Priya VeeraraghavanDepartment of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Selvaraj JayaramanDepartment of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the molecular docking analysis of four analogues of metformin [1-Carbamimidoyl-1,2-dimethylguanidine hydrochloride, Metformin hydrochloride, N1,N1-Dimethyl-N5-methylbiguanide hydrochloride, and N1,N1,N5,N5-Tetrakis (methyl-biguanide hydrochloride] with GSK3.

Indexed as

Diabetes mellitusGSK-3βMetformin analoguesMolecular docking studies

Identifiers

PMID36518134
PMCPMC9722410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.