Evidence map›Paper›PMID 36518053›Full record

SynthesisJournal of Zhejiang University. Science. B2022

Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis.

Rui Huang, Pan Liu, Yiguang Bai, Jieqiong Huang, Rui Pan, Huihua Li, Yeping Su, Quan Zhou, Ruixin Ma, Shaohui Zong and 1 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of Zhejiang University. Science. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. The gut-bone-inflammation axis: intestinal barrier disruption as a central driver of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Gut microbiome in early life and bone health outcomes at age 6: a Danish mother-child cohort study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  11. Review
  12. Probiotics and muscle health: the impact ofFrontiers in microbiology · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Frontiers in microbiology · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rui HuangCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China.
Pan LiuDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Yiguang BaiDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Jieqiong HuangCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China.
Rui PanCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China.
Huihua LiCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China.
Yeping SuCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China.
Quan ZhouDepartment of Wound Repair, the First People's Hospital of Nanning, Nanning 530022, China.
Ruixin MaDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Shaohui ZongDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. xiaohui3008@126.com.
Gaofeng ZengCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China. xiaohui3008@126.com, fengfeng_388@126.com.
Guangxi Medical University · CNFirst People's Hospital of Nanning · CNNorth Sichuan Medical University · CN

Funding

the Guangxi Hundred Thousand Talents Project [2019]32the Guangxi Medical High-level Backbone Talents Training "139" Program Training Project [2020]15the National Natural Science Foundation of China 81860391
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gastrointestinal MicrobiomeOsteoporosisRNA, Ribosomal, 16SAgedFecesGenes, rRNAHumansMiddle AgedRNA, Ribosomal, 16S16S ribosomal RNA (rRNA) sequencingIntestinalMicrobiomeOsteoporosis

Identifiers

PMID36518053
PMCPMC9758719
OpenAlexW4312065670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.