Evidence map›Paper›PMID 36517890›Full record

ArticleActa neuropathologica communications2022

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.

Jennifer L Brown, Damyan W Hart, Gabriel E Boyle, Taylor G Brown, Michael LaCroix, Andrés M Baraibar, Ross Pelzel, Minwoo Kim, Mathew A Sherman, Samuel Boes and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Jennifer L BrownGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Damyan W HartDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Gabriel E BoyleDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Taylor G BrownDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Michael LaCroixDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Andrés M BaraibarDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Ross PelzelGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Minwoo KimDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Mathew A ShermanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Samuel BoesDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Michelle SungDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Tracy ColeIonis Pharmaceuticals Inc., Carlsbad, CA, USA.
Michael K LeeDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Alfonso AraqueGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Sylvain E LesnéGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA. lesne002@umn.edu.ORCID http://orcid.org/0000-0001-9411-1868
University of Minnesota · USIonis Pharmaceuticals (United States) · US

Funding

Regulation of human tau expression and tauopathy by alpha-synucleinR01AG077743 · NIA · UNIVERSITY OF MINNESOTA · PI MICHAEL K LEE · 2022 to 2026
$3.8M
Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
AMP-Kinase as a target for neuroprotection in ADRF1AG062135 · NIA · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K, TRUSHINA, EUGENIA · 2019 to 2019
$3.2M
Tau-dependent cognitive deficits in alpha-synucleinopathiesR01NS108686 · NINDS · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, LEE, MICHAEL K · 2018 to 2022
$2.8M
Soluble αSyn is a modulator of AD pathophysiologyRF1AG044342 · NIA · UNIVERSITY OF MINNESOTA · PI LESNE, SYLVAIN E. · 2019 to 2019
$2.7M
Revealing Epistasis in Alzheimer DiseaseR01AG020135 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MARTIN, EDEN R. · 2002 to 2006
$2.7M
Astrocyte activity in amygdala-related fear conditioned behaviorsR01MH119355 · NIMH · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, KOFUJI, PAULO · 2020 to 2024
$2.3M
Pathological role of c-Abl in alpha-synucleinoapathyR01NS092093 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2016 to 2020
$2.2M
Decision-making alterations in mouse models of Alzheimer's diseaseRF1AG070296 · NIA · UNIVERSITY OF MINNESOTA · PI LESNE, SYLVAIN E. · 2021 to 2021
$1.8M
Role of astrocytes in dopamine signaling and psychostimulant effectsR01DA048822 · NIDA · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO · 2019 to 2023
$1.8M
Klotho and Neurodegenerative DiseaseR01NS092918 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2016 to 2020
$1.7M
Unfolded Protein Response in Alpha-synucleinopathiesR01NS086074 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2014 to 2018
$1.7M
NIA NIH HHS R01 AG020135NIA NIH HHS R01 AG044342NIA NIH HHS R01 AG077743NIA NIH HHS R21 AG065693NIA NIH HHS R56 AG074473NIA NIH HHS RF1 AG044342NIA NIH HHS RF1 AG062135NIA NIH HHS RF1 AG070296NIDA NIH HHS R01 DA048822NINDS NIH HHS F31 NS125963NINDS NIH HHS R01 NS086074NINDS NIH HHS R01 NS092093NINDS NIH HHS R01 NS092918NINDS NIH HHS R01 NS108686NINDS NIH HHS R56 NS113549NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Antisense oligonucleotide (ASO) therapy for neurological disease has been successful in clinical settings and its potential has generated hope for Alzheimer's disease (AD). We previously described that ablating SNCA encoding for α-synuclein (αSyn) in a mouse model of AD was beneficial. Here, we sought to demonstrate whether transient reduction of αSyn expression using ASO

Indexed as

alpha-SynucleinAlzheimer DiseaseCognitionAnimalsDisease Models, AnimalFemaleGene ExpressionMaleMiceMice, Inbred C57BLMice, KnockoutMice, Transgenicalpha-SynucleinSnca protein, mouseAlpha-synucleinAlzheimer’s diseaseAntisense oligonucleotideEarly growth response 1SexSpatial memorySynucleinopathy

Identifiers

PMID36517890
PMCPMC9749314
OpenAlexW4311364207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.