ArticleNature2023
Microglia regulate central nervous system myelin growth and integrity.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 297 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 1 pooled it
35.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
297 citing papers in PubMed, 1 synthesis or guideline pooled it, 441 citations in OpenAlex.
- Multimodal microglial and kynurenine pathway alterations across the affective-psychosis spectrum: a systematic review of patterns, heterogeneity, and dimensional implications.Molecular psychiatry · 2026Pooled it
- Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial.International journal of molecular sciences · 2025Trial
- Cell-specific expression of APP and GABABrain research · 2026Article
- CD11c + microglia: From basic research to clinical application.Neural regeneration research · 2026Article
- The cGAS-STING Pathway: A Double-Edged Regulator of Neuroinflammation and Myelin Regeneration.Molecular neurobiology · 2026Review
- Article
- SNX3 exacerbates hepatic fibrosis by amplifying TGF-Acta pharmaceutica Sinica. B · 2026Article
- Viridicatin from the Antarctic FungusAntioxidants (Basel, Switzerland) · 2026Article
- Oligodendrocyte dysfunction in human age-related cognitive decline.Nature medicine · 2026Article
- Review
- Deletion ofBiology · 2026Article
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- Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.Cell metabolism · 2026Article
- Microglial maturation across human and mouse as a reference for interpreting large-animal models of perinatal brain injury.Pediatric research · 2026Review
- Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.Nature neuroscience · 2026Article
- Cholesterol Drives IFITM3CNS neuroscience & therapeutics · 2026Article
- From astrocyte cholesterol synthesis to synaptic dysfunction: mechanisms of neuron-glia lipid coupling.Molecular biology reports · 2026Review
- Spinal signatures of entrenched and treated neuropathic pain in male mice.Nature communications · 2026Article
- Human umbilical cord blood mononuclear cells ameliorate vascular dementia by modulating microglial myelin debris handling and white matter injury.Journal of neuroinflammation · 2026Article
- Role Shift of Glial Cells from Physiology to Pathology in Alzheimer's Disease: The Regulatory Impact of Exercise.Neuroscience bulletin · 2026Review
237 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
28 authors at 12 institutions in 5 countries.
Niamh B McNamaraUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9769-367X
David A D MunroUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.
Nadine Bestard-CucheCentre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Akiko UyedaDepartments of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Jeroen F J BogieDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Alana HoffmannUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.
Rebecca K HollowayUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9396-7776
Irene Molina-GonzalezUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5966-0351
Katharine E AskewCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
Stephen MitchellWellcome Trust Centre for Cell Biology, King's Buildings, The University of Edinburgh, Edinburgh, UK.
William MungallBiological and Veterinary Services, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
Michael DoddsBiological and Veterinary Services, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
Carsten DittmayerDepartment of Neuropathology and Neurocure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Jonathan MossCentre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Jamie RoseUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.
Stefan SzymkowiakUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.
Lukas AmannInstitute of Neuropathology, Centre for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-8363-373X
Barry W McCollUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0521-9656
Marco PrinzInstitute of Neuropathology, Centre for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-0349-1955
Tara L Spires-JonesUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2530-0598
Werner StenzelDepartment of Neuropathology and Neurocure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Karen HorsburghCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
Jerome J A HendriksDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.ORCID http://orcid.org/0000-0002-7717-8582
Clare PridansCentre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9423-557X
Rieko MuramatsuDepartments of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID http://orcid.org/0000-0001-5342-7823
Anna WilliamsUK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6329-382X
Josef Priller *UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.
Veronique E Miron *UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. Veronique.Miron@unityhealth.to.ORCID http://orcid.org/0000-0003-1738-0647
UK Dementia Research Institute · GBUniversity of Edinburgh · GBMRC Centre for Regenerative Medicine · GBMRC Centre for Reproductive Health · GBCharité - Universitätsmedizin Berlin · DEHasselt University · BENational Center of Neurology and Psychiatry · JPSt. Michael's Hospital · CAUniversity of Freiburg · DEMaxwell Institute for Mathematical Sciences · GBTUM Klinikum · DEWellcome Centre for Cell Biology · GB
Funding
Medical Research Council MR/L003384/1Medical Research Council MR/M019969/1Medical Research Council MR/M020827/1Medical Research Council MR/T015594/1Medical Research Council MR/V031260/1Wellcome Trust
Abstract
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health
Indexed as
Central Nervous SystemMicrogliaMyelin SheathAdultAgingAnimalsAxonsCognitionHumansLipid MetabolismMiceNeurodegenerative DiseasesOligodendrogliaReceptor, Transforming Growth Factor-beta Type ITransforming Growth Factor beta1Receptor, Transforming Growth Factor-beta Type ITransforming Growth Factor beta1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.