ArticleScientific reports2022
The impact of depression and physical multimorbidity on health-related quality of life in China: a national longitudinal quantile regression study.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- The effect of different exercise modalities on older adults' quality of life: an assessor-blinded randomized controlled trial.Scientific reports · 2025Trial
- Lifestyle and psychosocial determinants of quality of life in Turkish community-dwelling older adults: a multivariate and hierarchical regression approach.BMC geriatrics · 2026Article
- The impact of self-efficacy on health-related quality of life among community-dwelling older adults with chronic diseases: the mediating role of self-management behaviour.Frontiers in public health · 2026Article
- Health-related quality of life of unemployed individuals diagnosed with a mental illness: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Measuring individual and community capacity factors in people with multimorbidity and exploring associations with health outcomes.BMC medicine · 2025Article
- Chronic disease clusters and health-related quality of life among individuals with musculoskeletal pain: a Northern Finland Birth Cohort 1966 study.Family practice · 2025Article
- Impact of physical activity on the depression and self-care ability among Chinese older adults during the COVID-19 pandemic: propensity score matching analysis.BMC geriatrics · 2025Article
- Navigating the depths: A comprehensive narrative review on depression in people with epilepsy.Heliyon · 2025Review
- Analysis of the current situation and factors influencing the utilization of somatic and somatic-mental disorder comorbidity and health services among middle-aged and older adult people in China.Frontiers in public health · 2025Article
- Article
- Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.Nature communications · 2024Article
- Effect of community-based public health service on health-related quality of life among middle-aged and older adults with chronic diseases in China.BMC public health · 2024Article
- Defining and measuring complex multimorbidity: a critical analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Functional limitation as a mediator of the relationship between multimorbidity on health-related quality of life in Australia: evidence from a national panel mediation analysis.Frontiers in medicine · 2023Article
- Multimorbidity and health related quality of life in U.S. adults: A population-based study.Journal of multimorbidity and comorbidityArticle
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The co-occurrence of mental and physical chronic conditions is a growing concern and a largely unaddressed challenge in low-and-middle-income countries. This study aimed to investigate the independent and multiplicative effects of depression and physical chronic conditions on health-related quality of life (HRQoL) in China, and how it varies by age and gender. We used two waves of the China Health and Retirement Longitudinal Study (2011, 2015), including 9227 participants aged ≥ 45 years, 12 physical chronic conditions and depressive symptoms. We used mixed-effects linear regression to assess the effects of depression and physical multimorbidity on HRQoL, which was measured using a proxy measure of Physical Component Scores (PCS) and Mental Component Scores (MCS) of the matched SF-36 measure. We found that each increased number of physical chronic conditions, and the presence of depression were independently associated with lower proxy PCS and MCS scores. There were multiplicative effects of depression and physical chronic conditions on PCS (- 0.83 points, 95% CI - 1.06, - 0.60) and MCS scores (- 0.50 points, 95% CI - 0.73, - 0.27). The results showed that HRQoL decreased markedly with multimorbidity and was exacerbated by the presence of co-existing physical and mental chronic conditions.
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