Evidence map›Paper›PMID 36517413›Full record

ArticleJournal of clinical lipidology

The independent associations of anti-Müllerian hormone and estradiol levels over the menopause transition with lipids/lipoproteins: The Study of Women's health Across the Nation.

Samar R El Khoudary, Xirun Chen, Meiyuzhen Qi, Carol A Derby, Maria M Brooks, Rebecca C Thurston, Imke Janssen, Sybil Crawford, Jennifer S Lee, Elizabeth A Jackson and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition.The Journal of clinical endocrinology and metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Samar R El KhoudaryDepartment of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Clinical and Translational Science Institute, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260, United States. Electronic address: elkhoudarys@edc.pitt.edu.
Xirun ChenDepartment of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Clinical and Translational Science Institute, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260, United States.
Meiyuzhen QiDepartment of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Clinical and Translational Science Institute, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260, United States.
Carol A DerbyAlbert Einstein College of Medicine Department of Neurology and Department of Epidemiology & Public Health, Bronx, NY, United States.
Maria M BrooksDepartment of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Clinical and Translational Science Institute, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260, United States.
Rebecca C ThurstonDepartment of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Clinical and Translational Science Institute, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260, United States; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Imke JanssenDepartment of Preventive Medicine, Rush University Rush Medical Center, Chicago, IL, United States.
Sybil CrawfordUniversity of Massachusetts Tan Chingfen Graduate School of Nursing at UMass Chan Medical School, Worcester, MA, United States.
Jennifer S LeeDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, United States; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States.
Elizabeth A JacksonUniversity of Alabama at Birmingham School of Medicine, Birmingham, AL, United States.
Claudia U ChaeMassachusetts General Hospital, Boston, MA, United States.
Daniel McConnellUniversity of Michigan Department of Epidemiology, Ann Arbor, MI, United States.
Karen A MatthewsDepartment of Epidemiology, Epidemiology Data Center, University of Pittsburgh Graduate School of Public Health, Clinical and Translational Science Institute, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260, United States; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
University of Pittsburgh · USAlbert Einstein College of Medicine · USMassachusetts General Hospital · USRush University Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Massachusetts Chan Medical School · USUniversity of Michigan · USVA Palo Alto Health Care System · US

Funding

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria Mori Brooks · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
SWAN Repository IVU01AG017719 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 2000 to 2020
$25.0M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Application of ambulatory methods for assessing short- and long-term associations of sleep health with cognitive decline in older adultsR01AG062622 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BUXTON, ORFEU M, DERBY, CAROL A. · 2019 to 2022
$3.1M
NIA NIH HHS R01 AG062622NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U01 AG017719NIA NIH HHS U19 AG063720NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

backgroundThe menopause transition (MT) is linked to adverse changes in lipids/lipoproteins. However, the related contributions of anti-Müllerian hormone (AMH) and estradiol (E2) are not clear.

objectiveTo evaluate the independent associations of premenopausal AMH and E2 levels and their changes with lipids/lipoproteins levels [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB) and apolipoprotein A-1 (apoA-1)] over the MT.

methodsSWAN participants who transitioned to menopause without exogenous hormone use, hysterectomy, or bilateral oophorectomy with data available on both exposure and outcomes when they were premenopausal until the 1st visit postmenopausal were studied.

resultsThe study included 1,440 women (baseline-age:mean±SD=47.4±2.6) with data available from up to 9 visits (1997-2013). Lower premenopausal levels and greater declines in AMH were independently associated with greater TC and HDL-C, whereas lower premenopausal levels and greater declines in E2 were independently associated with greater TG and apo B and lower HDL-C. Greater declines in AMH were independently associated with greater apoA-1, and greater declines in E2 were independently associated with greater TC and LDL-C.

conclusionsAMH and E2 and their changes over the MT relate differently to lipids/lipoproteins profile in women during midlife. Lower premenopausal and/or greater declines in E2 over the MT were associated with an atherogenic lipid/lipoprotein profile. On the other hand, lower premenopausal AMH and/or greater declines in AMH over the MT were linked to higher apo A-1 and HDL-C; the later found previously to be related to a greater atherosclerotic risk after menopause.

Indexed as

Anti-Mullerian HormoneLipoproteinsAdultApolipoprotein A-IApolipoproteins BCholesterol, HDLCholesterol, LDLEstradiolFemaleHumansMenopauseMiddle AgedTriglyceridesWomen's HealthAnti-Mullerian HormoneApolipoprotein A-IApolipoproteins BCholesterol, HDLCholesterol, LDLEstradiolLipoproteinsTriglyceridesAnti-Müllerian hormoneEstradiolLipids/apolipoproteinsMenopause transition

Identifiers

PMID36517413
PMCPMC9974763
OpenAlexW4309726556

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.