ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
The Protective Effect of Social Reward on Opioid and Psychostimulant Reward and Relapse: Behavior, Pharmacology, and Brain Regions.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 30 citations in OpenAlex.
- Methamphetamine-Fentanyl Polysubstance Administration Produces Social Deficits and Corticolimbic Stress-Reward Circuit Adaptations.Research square · 2026Article
- Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse.Nature communications · 2026Article
- Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits.Addiction biology · 2026Article
- Enhancing care in alcohol-associated liver disease through peer support for alcohol use disorder.Hepatology communications · 2026Review
- Renewal and reacquisition of substance-associated relapse.Frontiers in psychology · 2026Review
- Pairing Mouse Social and Aversive Stimuli across Sexes Does Not Produce Social Aversion in Females.eNeuro · 2025Article
- A rat model of volitional mutual social interactions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Male and female mice may respectively form stronger social aversive memories with same and different sex conspecifics.bioRxiv : the preprint server for biology · 2025Article
- An automated group-housed oral fentanyl self-administration method in mice.Psychopharmacology · 2025Article
- Operant social self-administration in male CD1 mice.Psychopharmacology · 2025Article
- Time to choose: impact of intertrial interval on selecting between methamphetamine and food reinforcement in male and female rats.Psychopharmacology · 2025Article
- Neurobiology of the incubation of drug craving: An update.Pharmacological reviews · 2025Review
- Animal models of cocaine use: importance of social context and co-use.Trends in pharmacological sciences · 2025Review
- It takes two: The interplay between dopamine and oxytocin in social behavior.Neuroscience and biobehavioral reviews · 2025Article
- Remission from addiction: erasing the wrong circuits or making new ones?Nature reviews. Neuroscience · 2025Review
- The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus.Psychopharmacology · 2025Article
- Minibox: Custom solo or semi-group housing chambers for long term housing of rats with miniscopes.MethodsX · 2024Article
- The subjective value of social context in people who use cannabis.Experimental and clinical psychopharmacology · 2024Article
- Relapse after electric barrier-induced voluntary abstinence: A review.Current opinion in neurobiology · 2024Review
- Neuroscience in addiction research.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Until recently, most modern neuroscience research on addiction using animal models did not incorporate manipulations of social factors. Social factors play a critical role in human addiction: social isolation and exclusion can promote drug use and relapse, while social connections and inclusion tend to be protective. Here, we discuss the state of the literature on social factors in animal models of opioid and psychostimulant preference, self-administration, and relapse. We first summarize results from rodent studies on behavioral, pharmacological, and circuit mechanisms of the protective effect of traditional experimenter-controlled social interaction procedures on opioid and psychostimulant conditioned place preference, self-administration, and relapse. Next, we summarize behavioral and brain-mechanism results from studies using newer operant social-interaction procedures that inhibit opioid and psychostimulant self-administration and relapse. We conclude by discussing how the reviewed studies point to future directions for the addiction field and other neuroscience and psychiatric fields, and their implications for mechanistic understanding of addiction and development of new treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.