ArticleBritish journal of sports medicine2023
Traumatic encephalopathy syndrome: application of new criteria to a cohort exposed to repetitive head impacts.
Article in British journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion.Neurobiology of disease · 2026Review
- Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuropsychological Health in Mixed Martial Arts Fighters and Combat Sport Athletes: A Scoping Review.Cureus · 2026Review
- Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts.Alzheimer's research & therapy · 2026Article
- Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts.Research square · 2026Article
- Base rates of healthy community-dwelling adults meeting criteria for traumatic encephalopathy syndrome and levels of chronic traumatic encephalopathy certainty.The Clinical neuropsychologist · 2025Article
- Brain health concerns in former rugby players: clinical and cognitive phenotypes.Brain : a journal of neurology · 2025Article
- Biomarker evidence of neurodegeneration in mid-life former rugby players.Brain : a journal of neurology · 2025Article
- Traumatic Encephalopathy Syndrome in the Late Effects of Traumatic Brain Injury (LETBI) Study Cohort.Neurology open access · 2025Article
- Symptoms of Traumatic Encephalopathy Syndrome are Common in Community-Dwelling Adults.Sports medicine (Auckland, N.Z.) · 2024Article
- Article
- Interaction of Medical Conditions and Football Exposures Associated with Premortem Chronic Traumatic Encephalopathy Diagnosis in Former Professional American Football Players.Sports medicine (Auckland, N.Z.) · 2024Article
- Medical Conditions in Former Professional American-Style Football Players Are Associated With Self-Reported Clinical Features of Traumatic Encephalopathy Syndrome.Neurotrauma reports · 2024Article
- Applying the Consensus Criteria for Traumatic Encephalopathy Syndrome Retrospectively to Case Studies of Boxers from the 20th Century.Neurotrauma reports · 2024Article
- Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges.Biomedicines · 2023Review
- Longitudinal Changes in Regional Brain Volumes and Cognition of Professional Fighters With Traumatic Encephalopathy Syndrome.Neurology · 2023Article
- Updated Review of Neurologic Concussion Biomarkers for Time-sensitive Point-of-care Testing.Journal of emergencies, trauma, and shockReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the characteristics of those who fulfil the recent National Institute of Neurological Disease and Stroke (NINDS) Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome (TES) and test whether they show differences in MRI-based regional brain volumes, cognitive domains, and certain plasma biomarkers.
methodsProfessional fighters 35 years of age or older and/or retired were included. Participants were categorised as either having TES (TES+) or not (non-TES). TES+ participants were further subtyped by their cognitive profile. Multiple linear regression models were used to compare MRI-based regional brain volumes, cognitive performance, plasma tau and neurofilament light levels between TES- and TES+ groups.
results176 participants (110 boxers and 66 MMA) were included in the analysis. 72 (41%)/176 were categorised as having TES, the likelihood of TES increasing with age. TES+ participants tended to be boxers, started fighting at a younger age, had more professional fights and knocked out more frequently. The TES+ group had lower regional brain volumes including both grey and white matter structures. TES+ also had lower scores on simple and choice reaction time, psychomotor speed and Trails A .
conclusionThe new TES criteria does distinguish a group of fighters with differences in regional brain volumes and reduced cognitive function. Our findings support the use of the NINDS criteria for TES in further research of the long-term effects of repetitive head impacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.