Evidence map›Paper›PMID 36517209›Full record

ArticleJournal of medicinal chemistry2023

Exploring the Effect of Halogenation in a Series of Potent and Selective A

Rubén Prieto-Díaz, Manuel González-Gómez, Hugo Fojo-Carballo, Jhonny Azuaje, Abdelaziz El Maatougui, Maria Majellaro, María I Loza, José Brea, Víctor Fernández-Dueñas, M Rita Paleo and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. APurinergic signalling · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Rubén Prieto-DíazCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0003-2539-3106
Manuel González-GómezCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
Hugo Fojo-CarballoCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
Jhonny AzuajeCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
Abdelaziz El MaatouguiCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
Maria MajellaroCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
María I LozaCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0003-4730-0863
José BreaCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0002-5523-1979
Víctor Fernández-DueñasPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, 08907L'Hospitalet de Llobregat, Spain.
M Rita PaleoCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0002-0095-3931
Alejandro Díaz-HolguínDepartment of Cell and Molecular Biology, Uppsala University, Biomedical Center, 75124Uppsala, Sweden.
Beatriz Garcia-PinelCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0002-4473-7659
Ana Mallo-AbreuCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0002-5092-3538
Juan C EstévezCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0001-9468-9045
Antonio Andújar-AriasCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0001-9922-3543
Xerardo García-MeraDepartment of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
Iria Gomez-TourinoCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neuroscience, University of Barcelona, 08907L'Hospitalet de Llobregat, Spain.ORCID 0000-0003-0832-3739
Cristian O SalasDepartment of Organic Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago7820436, Chile.
Hugo Gutiérrez-de-TeránDepartment of Cell and Molecular Biology, Uppsala University, Biomedical Center, 75124Uppsala, Sweden.ORCID 0000-0003-0459-3491
Eddy SoteloCenter for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, 15782Santiago de Compostela, Spain.ORCID 0000-0001-5571-2812
Universidade de Santiago de Compostela · ESUppsala University · SEInstitut d'Investigació Biomédica de Bellvitge · ESPontificia Universidad Católica de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modulation of the A

Indexed as

HalogenationPurinergic P1 Receptor AntagonistsAdenosine A2 Receptor AntagonistsAnimalsCHO CellsCricetinaeHalogensHumansLeukocytes, MononuclearLigandsReceptor, Adenosine A2BAdenosine A2 Receptor AntagonistsHalogensLigandsPurinergic P1 Receptor AntagonistsReceptor, Adenosine A2B

Identifiers

PMID36517209
PMCPMC9841532
OpenAlexW4311572976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.