Evidence map›Paper›PMID 36516994›Full record

ArticleOrganic letters2022

Photochemical Dimerization of Plakinidine B Leads to Potent Inhibition of the E3 Ubiquitin-Protein Ligase CBL-B.

Quan T Khong, Donghao Li, Brice A P Wilson, Kalina Ranguelova, Masoumeh Dalilian, Emily A Smith, Antony Wamiru, Ekaterina I Goncharova, Tanja Grkovic, Donna Voeller and 4 more

Abstract read
In one paragraph

Article in Organic letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chemoreactive 2,5-Diketopiperazines from aJournal of natural products · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Quan T KhongMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Donghao LiChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 20850, United States.ORCID 0000-0003-2556-1624
Brice A P WilsonMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.ORCID 0000-0001-8988-1964
Kalina RanguelovaBruker BioSpin Corp, Billerica, Massachusetts 01821, United States.
Masoumeh DalilianMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Emily A SmithMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Antony WamiruMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Ekaterina I GoncharovaMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Tanja GrkovicMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.ORCID 0000-0002-6537-3997
Donna VoellerWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1578, United States.
Stanley LipkowitzWomen's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1578, United States.
Martin J SchnermannChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 20850, United States.ORCID 0000-0002-0503-0116
Barry R O'KeefeMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.ORCID 0000-0003-0772-4856
Lin DuMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.ORCID 0000-0001-8751-4482

Funding

Natural Products Discovery and Characterization Through Network CollaborationsZIABC011568 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DU, LIN · 2014 to 2025
$17.2M
Near-IR Photorelease Chemistry: Discovery and ApplicationsZIABC011564 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNERMANN, MARTIN · 2014 to 2025
$9.5M
NCI Program for Natural Products Discovery - CuresZIABC011854 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OKEEFE, BARRY · 2020 to 2025
$5.2M
Intramural NIH HHS ZIA BC011564Intramural NIH HHS ZIA BC011568Intramural NIH HHS ZIA BC011854NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

A new dimeric alkaloid plakoramine A [(±)-

Indexed as

Dimerization

Identifiers

PMID36516994
PMCPMC10681237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.