Evidence map›Paper›PMID 36516918›Full record

ArticleAmerican journal of ophthalmology2023

Comparison of Ganglion Cell Layer and Inner Plexiform Layer Rates of Change in Suspected and Established Glaucoma.

Massood Mohammadi, Erica Su, Leila Chew, Vahid Mohammadzadeh, Joseph Caprioli, Robert E Weiss, Kouros Nouri-Mahdavi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. A Pattern-Based OCT Metric for Glaucoma Detection.Translational vision science & technology · 2024
    Article
  4. Article
  5. A Model of Progression to Help Identify Macular Damage Due to Glaucoma.Investigative ophthalmology & visual science · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Massood MohammadiFrom the Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine (M.M., L.C., V.M., J.C., K.N-M.), University of California Los Angeles, Los Angeles, California, USA.
Erica SuDepartment of Biostatistics, Fielding School of Public Health (E.S., R.E.W.), University of California Los Angeles, Los Angeles, California, USA.
Leila ChewFrom the Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine (M.M., L.C., V.M., J.C., K.N-M.), University of California Los Angeles, Los Angeles, California, USA.
Vahid MohammadzadehFrom the Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine (M.M., L.C., V.M., J.C., K.N-M.), University of California Los Angeles, Los Angeles, California, USA.
Joseph CaprioliFrom the Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine (M.M., L.C., V.M., J.C., K.N-M.), University of California Los Angeles, Los Angeles, California, USA.
Robert E WeissDepartment of Biostatistics, Fielding School of Public Health (E.S., R.E.W.), University of California Los Angeles, Los Angeles, California, USA.
Kouros Nouri-MahdaviFrom the Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine (M.M., L.C., V.M., J.C., K.N-M.), University of California Los Angeles, Los Angeles, California, USA. Electronic address: nouri-mahdavi@jsei.ucla.edu.
University of California, Los Angeles · US

Funding

Detection of Disease Progression in Advanced GlaucomaR01EY029792 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NOURI-MAHDAVI, KOUROS · 2020 to 2024
$1.9M
NEI NIH HHS R01 EY029792
6 · The paper itself

Abstract

purposeWe compared ganglion cell layer (GCL) and inner plexiform layer (IPL) rates of change (RoC) in patients with glaucoma suspect (GS) and established glaucoma (EG) to test the hypothesis that IPL thickness changes would occur earlier than GCL changes in eyes with early damage.

designProspective, cohort study.

methodsA total of 64 GS eyes (46 patients) and 112 EG eyes (112 patients) with ≥2 years of follow-up and ≥3 macular optical coherence tomography scans were included. GCL and IPL superpixel thickness measurements were exported. A Bayesian hierarchical model with random intercepts/slopes and random residual variances was fitted to estimate RoC in individual superpixels. Normalized RoC and proportions of superpixels with significantly negative and positive GCL and IPL RoC were compared within the groups.

resultsThe average (SD) follow-up time and number of scans were 3.5 (0.7) years and 4.2 (1.0), respectively, in the GS group and 3.6 (0.4) years and 7.3 (1.1) in the EG group. Mean (SD) normalized RoC was faster for GCL than IPL (-0.69 [0.05] vs -0.33 [0.04]) in the GS group, whereas it was faster for IPL (-0.47 [0.03] vs -0.28 [0.02]) in EG eyes. GCL RoC were significantly negative in 24 of 36 superpixels compared with 8 of 36 for IPL (P < .001) in GS eyes. In the EG group, 23 of 36 superpixels had significant negative IPL RoC compared with 13 of 36 superpixels for GCL (P = .006).

conclusionsGCL thickness is more likely to demonstrate change over time compared with IPL in glaucoma suspects. There is no evidence of preferential IPL thinning in eyes with suspected early glaucoma damage.

Indexed as

GlaucomaRetinal Ganglion CellsBayes TheoremCohort StudiesCross-Sectional StudiesHumansIntraocular PressureNerve FibersProspective StudiesTomography, Optical Coherence

Identifiers

PMID36516918
PMCPMC10106372
OpenAlexW4311425176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.