Evidence map›Paper›PMID 36516861›Full record

ArticleCell metabolism2023

Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo.

Brandon T Hubbard, Traci E LaMoia, Leigh Goedeke, Rafael C Gaspar, Katrine D Galsgaard, Mario Kahn, Graeme F Mason, Gerald I Shulman

Open access · greenAbstract read
In one paragraph

Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Insulin receptorNature communications · 2026
    Article
  2. Sarco/Endoplasmic Reticulum CaJournal of the American Heart Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brandon T HubbardDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Traci E LaMoiaDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
Leigh GoedekeDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Rafael C GasparDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Katrine D GalsgaardDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Mario KahnDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Graeme F MasonDepartment of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Psychiatry & Biomedical Engineering, Yale School of Medicine, New Haven, CT 06510, USA.
Gerald I ShulmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: gerald.shulman@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
In vivo Pathway Discovery in Autosomal Dominant Polycystic Kidney DiseaseRC2DK120534 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J., SHULMAN, GERALD I · 2019 to 2023
$6.6M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32GM007324 · NIGMS · YALE UNIVERSITY · PI BENNETT, ANTON M · 1987 to 2022
$6.2M
Yale Center for Metabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK134901 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 2023 to 2026
$3.8M
Effects of Hepatic Acetyl-CoA Carboxylase Inhibition on NAFLD and Hepatic Insulin ResistanceR01DK113984 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2017 to 2021
$3.7M
Development of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human PrimatesR01DK119968 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2019 to 2024
$2.7M
Mechanism of Renal Cortical Insulin ResistanceR01DK133143 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2022 to 2025
$2.3M
Relationship of Brain Ethanol Oxidation with BehaviorR21AA028628 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2020 to 2021
$440k
Cellular and molecular mechanisms of diabetic atherosclerosisK99HL150234 · NHLBI · YALE UNIVERSITY · PI GOEDEKE, LEIGH · 2020 to 2021
$214k
Elucidating the pathophysiology and molecular mechanisms of renal insulin resistanceF30DK131846 · NIDDK · YALE UNIVERSITY · PI HUBBARD, BRANDON · 2022 to 2025
$173k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K99 HL150234NIAAA NIH HHS R21 AA028628NIDDK NIH HHS F30 DK131846NIDDK NIH HHS F31 DK126362NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK113984NIDDK NIH HHS R01 DK119968NIDDK NIH HHS R01 DK133143NIDDK NIH HHS RC2 DK120534NIDDK NIH HHS U2C DK134901NIGMS NIH HHS T32 GM007324NIGMS NIH HHS T32 GM136651
6 · The paper itself

Abstract

The mammalian succinate dehydrogenase (SDH) complex has recently been shown as capable of operating bidirectionally. Here, we develop a method (Q-Flux) capable of measuring absolute rates of both forward (V

Indexed as

Methylmalonyl-CoA MutaseSuccinate DehydrogenaseAnimalsGlucoseGlutaminaseLiverProteinsPyruvic AcidRodentiaGlucoseGlutaminaseMethylmalonyl-CoA MutaseProteinsPyruvic AcidSuccinate Dehydrogenaseanaplerosisglucagonglutaminaseinsulinmass spectrometrymetabolic flux analysismethylmalonyl-CoA mutasemitochondrial metabolismpropionatesuccinate dehydrogenase

Identifiers

PMID36516861
PMCPMC9887731
OpenAlexW4311310363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.