Evidence map›Paper›PMID 36516788›Full record

ArticleActa cytologica2023

Cervical Epithelial Abnormalities and Associated Factors among HIV-Infected Women in Lagos, Nigeria: A Cytology-Based Study.

Kehinde S Okunade, Kabir B Badmos, Adaiah P Soibi-Harry, Sunusi-Rimi Garba, Ephraim O Ohazurike, Oluchi Ozonu, Alani S Akanmu, Folasade T Ogunsola, Fatimah B Abdulkareem, Rose I Anorlu

Open access · greenAbstract read
In one paragraph

Article in Acta cytologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kehinde S OkunadeDepartment of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
Kabir B BadmosDepartment of Anatomic and Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria.
Adaiah P Soibi-HarryOncology and Pathological Studies Unit, Lagos University Teaching Hospital, Lagos, Nigeria.
Sunusi-Rimi GarbaOncology and Pathological Studies Unit, Lagos University Teaching Hospital, Lagos, Nigeria.
Ephraim O OhazurikeOncology and Pathological Studies Unit, Lagos University Teaching Hospital, Lagos, Nigeria.
Oluchi OzonuOncology and Pathological Studies Unit, Lagos University Teaching Hospital, Lagos, Nigeria.
Alani S AkanmuDepartment of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria.
Folasade T OgunsolaDepartment of Medical Microbiology, College of Medicine, University of Lagos, Lagos, Nigeria.
Fatimah B AbdulkareemDepartment of Anatomic and Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria.
Rose I AnorluDepartment of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
University of Lagos · NGLagos University Teaching Hospital · NG

Funding

Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
Pathology and Genomics CoreU54CA221205 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOU, LIFANG, MURPHY, ROBERT LEO · 2017 to 2021
$4.2M
Nigeria HIV Research Training ProgramD43TW010934 · FIC · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2019 to 2026
$2.4M
COMParative ASSessment of p16/Ki-67 DUal Staining Technology in women living with HIV (COMPASS-DUST study)K43TW011930 · FIC · COLLEGE OF MEDICINE, UNIVERSITY OF LAGOS · PI KEHINDE SHARAFADEEN OKUNADE · 2022 to 2026
$500k
FIC NIH HHS D43 TW010543FIC NIH HHS D43 TW010934FIC NIH HHS K43 TW011930NCI NIH HHS U54 CA221205NIA NIH HHS U54 AG062334
6 · The paper itself

Abstract

introductionAs it may not be feasible to provide cervical cancer screening services to all HIV-infected women in most resource-limited settings, there is a need to identify those who are most at risk. We determined the prevalence, patterns, and associated factors of cervical cytological abnormalities among HIV-infected women in Lagos, Nigeria.

methodsThis descriptive cross-sectional study was conducted among HIV-infected women at the adult HIV treatment and colposcopy clinics of a university teaching hospital in Lagos, Nigeria, between October 2018 and December 2019. A cervical sample was collected from each woman to detect cervical cytological abnormalities.

resultsOf the 593 enrolled women, cervical cytological abnormalities were present in 40 (6.7%). Most (37.5%) of the women with cytological abnormalities had atypical squamous cells of undetermined significance. Age at coitarche (<20 vs. ≥20 years: adjusted odds ratio, 2.42; 95% confidence interval, 1.21-4.83, p = 0.01) was the only factor that was independently associated with cervical epithelial abnormalities.

conclusionThe prevalence of cervical cytological abnormalities in our study is lower than most previous reports in Africa. Sexual debut at an early age was significantly associated with cytological abnormalities. It is necessary to confirm the findings of this study through a well-designed and adequately powered longitudinal study.

Indexed as

HIV InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultCross-Sectional StudiesEarly Detection of CancerFemaleHumansLongitudinal StudiesNigeriaPapanicolaou TestVaginal SmearsAtypical squamous cells of undetermined significanceCervical cancerCytological abnormalitiesHIVNigeriaPapanicolaou smear

Identifiers

PMID36516788
PMCPMC10238562
OpenAlexW4311448207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.