ArticleCell reports2022
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 62 citations in OpenAlex.
- Mesenchyme-derived inflammation during the saccular stage recruits macrophages and alters lung development.JCI insight · 2026Article
- Alveolar macrophage-neutrophil crosstalk in acute lung injury: mechanisms, feedback loops, and therapeutic opportunities.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts.bioRxiv : the preprint server for biology · 2026Article
- A murine sinonasal infection model recapitulates key features of clinical chronic rhinosinusitis.Journal of medical microbiology · 2026Article
- The Involvement of MicroRNAs in Innate Immunity and Cystic Fibrosis Lung Disease: A Narrative Review.Current issues in molecular biology · 2026Review
- The role of macrophages in radiation-induced lung injury: from pathological mechanisms to therapeutic targets.Frontiers in immunology · 2026Review
- Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development.Theranostics · 2026Review
- Protective Role of Octreotide in Acute and Chronic Lung Injuries.International journal of preventive medicine · 2026Article
- Lung scRNA-seq reveals chronic inflammation and emphysemous phenotype in mice with osteogenesis imperfecta.Frontiers in genetics · 2026Article
- Recruited Monocyte-Derived Macrophages Drive T Cell Inflammation in Immune Checkpoint Inhibitor-Mediated Pneumonitis.Cancer communications (London, England) · 2026Article
- Reduction of systemic inflammation by elexacaftor/tezacaftor/ivacaftor correlates with lung function improvement in cystic fibrosis.The European respiratory journal · 2025Observational
- ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2025Article
- Machine Learning Integration of Bulk and Single-Cell RNA-Seq Data Reveals Cathepsin B as a Central PANoptosis Regulator in Influenza.International journal of molecular sciences · 2025Article
- Spectral immune cell profiling reveals modulations in immune cell response to repetitive inhaled organic dust exposure in a high omega-3 fatty acid mouse model.Lipids in health and disease · 2025Article
- Regulation of respiratory CD8+ T-cell immunity by suppressive monocyte-like dendritic cells (MCs).Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- CCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and cystic fibrosis mice.Journal of leukocyte biology · 2025Article
- Innate Immunity in Cystic Fibrosis: Varied Effects of CFTR Modulator Therapy on Cell-to-Cell Communication.International journal of molecular sciences · 2025Review
- Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025Review
- Development of a machine learning-based risk prediction model for early-stage pneumoconiosis: a retrospective study.Frontiers in medicine · 2025Article
- Where lung cancer and tuberculosis intersect: recent advances.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 3 countries.
Hasan H ÖzDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Ee-Chun ChengDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Caterina Di PietroDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Toma TebaldiDepartment of Hematology, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.
Giulia BianconDepartment of Hematology, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Caroline ZeissDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
Ping-Xia ZhangDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Pamela H HuangDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Sofia S EsquibiesDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Clemente J BrittoDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Jonas C SchuppDepartment of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.
Thomas S MurrayDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Stephanie HaleneDepartment of Hematology, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Diane S KrauseYale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Marie E EganDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Emanuela M BrusciaDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: emanuela.bruscia@yale.edu.
Yale University · USYale Cancer Center · USUniversity of Trento · IT
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MVector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5MYale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7MHematology Central Coordinating Center (HCCC) for the NIDDK Hematology Centers ProgramU24DK126127 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, DEREK L STIREWALT · 2020 to 2026
$7.5MRole of Ezrin in MacrophagesR01AI153422 · NIAID · YALE UNIVERSITY · PI BRUSCIA, EMANUELA MARINA · 2021 to 2025
$3.2MPathogenic monocyte response to chronic lung inflammation in cystic fibrosisR01HL157776 · NHLBI · YALE UNIVERSITY · PI BRUSCIA, EMANUELA MARINA · 2022 to 2025
$3.1MThe role of m6A RNA modification as modulator of dsRNA induced cell-intrinsic innate immune responses in hematopoiesisR01DK124788 · NIDDK · YALE UNIVERSITY · PI HALENE, STEPHANIE · 2021 to 2023
$884kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL157776NIAID NIH HHS R01 AI153422NIDDK NIH HHS P30 DK065988NIDDK NIH HHS R01 DK124788NIDDK NIH HHS U24 DK126127NIDDK NIH HHS U54 DK106857
Abstract
Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue deterioration in CF are not well characterized. Starting from the observation that, in patients with CF, c-c motif chemokine receptor 2 (CCR2)
Indexed as
Cystic FibrosisPneumoniaAnimalsCystic Fibrosis Transmembrane Conductance RegulatorHumansInflammationLungMacrophagesMiceMonocytesReceptors, ChemokineTransforming Growth Factor betaCystic Fibrosis Transmembrane Conductance RegulatorReceptors, ChemokineTransforming Growth Factor betac-c motif chemokine receptor 2chronic lung inflammationCP: Immunologycystic fibrosislipopolysaccharidelung remodelingmacrophagesmonocytesneutrophilsrecruitmenttransforming growth factor β
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.