Evidence map›Paper›PMID 36516647›Full record

ArticleJournal of infection and public health2023

The prevalence of adverse reactions among individuals with three-dose COVID-19 vaccination.

Yuying Wang, Yujie Zhang, Meng Zhang, Xiaoyu Zhang, Haibin Li, Youxin Wang, Wei Wang, Jianguang Ji, Lijuan Wu, Deqiang Zheng

Open access · goldAbstract read
In one paragraph

Article in Journal of infection and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Yuying WangDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China.
Yujie ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China.
Meng ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China; Department of Epidemiology and Bio-statistics, School of Public Health, Peking University, Beijing 100191, China.
Xiaoyu ZhangDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China.
Haibin LiHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Youxin WangDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China.
Wei WangCentre for Precision Health, Edith Cowan University, Perth, WA 6027, Australia.
Jianguang JiCenter for Primary Health Care Research, Lund University/Region Skåne, 20 502 Malmö, Sweden. Electronic address: jianguang.ji@med.lu.se.
Lijuan WuDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China. Electronic address: xiaowu@ccmu.edu.cn.
Deqiang ZhengDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China; Center for Primary Health Care Research, Lund University/Region Skåne, 20 502 Malmö, Sweden. Electronic address: dqzheng@ccmu.edu.cn.
Capital Medical University · CNLund University · SEBeijing Chao-Yang Hospital · CNEdith Cowan University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConsidering the adverse reactions to vaccination against coronavirus disease 2019 (COVID-19), some people, particularly the elderly and those with underlying medical conditions, are hesitant to be vaccinated. This study aimed to explore the prevalence of adverse reactions and provide direct evidence of vaccine safety, mainly for the elderly and people with underlying medical conditions, to receive COVID-19 vaccination.

methodsFrom 1st March to 30th April 2022, we conducted an online survey of people who had completed three doses of COVID-19 vaccination by convenience sampling. Adverse reaction rates and 95% confidence intervals were calculated. In addition, conditional logistic regression was used to compare the differences in adverse reactions among the elderly and those with underlying medical conditions with the general population.

resultsA total of 3339 individuals were included in this study, of which 2335 (69.9%) were female, with an average age of 32.1 ± 11.4 years. The prevalence of adverse reactions after the first dose of inactivated vaccine was 24.6% (23.1-26.2%), 19.2% (17.8-20.7%) for the second dose, and 19.1% (17.7-20.6%) for the booster dose; among individuals using messenger RNA vaccines, the prevalence was 42.7% (32.3-53.6%) for the first dose, 47.2% (36.5-58.1%) for the second dose, and 46.1% (35.4-57.0%) for the booster dose. Compared with the general population, the prevalence of adverse events did not differ in individuals with underlying medical conditions and those aged 60 and above.

conclusionsFor individuals with underlying medical conditions and those aged 60 and above, the prevalence of adverse reactions is similar to that of the general population, which provides a scientific basis regarding vaccination safety for these populations.

Indexed as

COVID-19COVID-19 VaccinesAdultAgedFemaleHumansMalePrevalenceResearch DesignVaccinationYoung AdultCOVID-19 VaccinesAdverse reactionsBooster doseCOVID-19 vaccineSARS-CoV-2Special populations

Identifiers

PMID36516647
PMCPMC9724502
OpenAlexW4310796690

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.