Evidence map›Paper›PMID 36516638›Full record

ArticlePsychiatry research2023

Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants.

Cassie Overstreet, Daniel F Levey, Hang Zhou, Kelly M Harrington, Rachel Quaden, Murray B Stein, Joel Gelernter, Robert H Pietrzak, Million Veteran Program

Abstract read
In one paragraph

Article in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Neurophenotypes of COVID-19: Risk factors and recovery outcomes.Brain, behavior, & immunity - health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cassie OverstreetDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut, United States. Electronic address: cassie.overstreet@yale.edu.
Daniel F LeveyDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut, United States.
Hang ZhouDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut, United States.
Kelly M HarringtonMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, United States; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, United States.
Rachel QuadenMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, United States.
Murray B SteinPsychiatry Service, VA San Diego Healthcare System, San Diego, CA, United States; Departments of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, United States.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States; Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut, United States.
Robert H PietrzakDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States; National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, United States.
Million Veteran ProgramDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States.

Funding

RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3M
Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.IK2BX005058 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI LEVEY, DANIEL F · 2021 to 2025
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BLRD VA IK2 BX005058CSRD VA I01 CX001849NIDA NIH HHS R01 DA054869NIMH NIH HHS T32 MH014276
6 · The paper itself

Abstract

The Million Veteran Program (MVP) uses the posttraumatic stress disorder symptoms (PTSD) Checklist 17 (PCL-17) self-report to assess PTSD. Existing literature suggests that the five-factor dysphoric arousal model best represents the PTSD symptom clusters; this can be tested within MVP, one of the largest samples collected with suitable data. We compared factor models within MVP across genetically defined subsamples (ancestry [European, African, admixed American, and East Asian], sex) via multi-group confirmatory factor analyses in a sample of 279,897 participants. The five-factor dysphoric arousal model best fit the PCL-17 data, consistent with previous findings. The factor structure could also be imposed across all groups tested. Verifying the factor structure provides a framework for future phenotypic and genotypic analyses within MVP and other samples.

Indexed as

Stress Disorders, Post-TraumaticVeteransChecklistDiagnostic and Statistical Manual of Mental DisordersFactor Analysis, StatisticalHumansSelf ReportFive factor dysphoric arousal modelMulti-group confirmatory factor analysisPosttraumatic stress disorder

Identifiers

PMID36516638
PMCPMC10184787

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.