ArticleAging2022
DNA methylation GrimAge version 2.
Open access · hybridAbstract read
In one paragraph
Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 286 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed, 1 pooled it
21.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
286 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.
- Meta-analysis of DNA methylation aging signatures in 17 human tissues.Nature aging · 2026Pooled it
- Trial
- Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy.Nature communications · 2026Trial
- Trial
- Epigenetic aging and DNA methylation biomarker changes following ketamine treatment in patients with MDD and PTSD: a pilot study.Translational psychiatry · 2025Trial
- Relationship intervention moderates the association between substance use and biological aging among Black adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Trial
- Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial).Scientific reports · 2025Trial
- Trial
- Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.Nature aging · 2025Trial
- Hypertension-associated DNA methylation signatures and multi-generational epigenetic clocks in Korean adults.GeroScience · 2026Article
- Associations of breast DNA methylation-based measures of biological ageing with obesity-related breast cancer risk markers.Epigenetics · 2026Article
- Epigenetic insights of Olympic champions: nuclear and mitochondrial DNA methylation and regulators of aging.GeroScience · 2026Article
- Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements.GeroScience · 2026Article
- DNA methylation-based surrogate markers of C-reactive protein and their associations with health-related traits.GeroScience · 2026Article
- Capturing wear in wear and tear: The negative-affect reactivity linked to discrimination is associated with biological age across two national samples of adults in the United States.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Blood cell composition reveals distinct biological interpretation of DNA methylation age and age acceleration.Genome medicine · 2026Article
- Substance use and epigenetic age acceleration: Associations with alcohol, tobacco, illicit drugs, and SUD severity.Drug and alcohol dependence · 2026Article
- PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals.GeroScience · 2026Article
- Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging cell · 2026Article
- Article
226 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 13 institutions in 2 countries.
Ake T LuDept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Alexandra M BinderPopulation Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Joshua ZhangDept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Qi YanSan Diego Institute of Science, Altos Labs, San Diego, CA 92121, USA.
Alex P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, UK.
Janie CorleyLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, UK.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, UK.
Pei-Lun KuoLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Ann Z MooreLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Stefania BandinelliGeriatric Unit, Local Health Unit Tuscany Centre, Firenze, Tuscany 40125, Italy.
James D StewartDept. of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516-8050, USA.
Cuicui WangDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Elissa J HamlatDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143-0848, USA.
Elissa S EpelDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143-0848, USA.
Joel D SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Eric A WhitselDept. of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516-8050, USA.
Adolfo CorreaDepartments of Medicine and Population Health Science, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, Scotland, UK.
Steve HorvathDept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
University of Edinburgh · GBFleet Science Center · USHarvard University · USNational Institutes of Health · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USAltos LabsEdinburgh Cancer Research · GBFred Hutch Cancer Center · USJackson Memorial Hospital · USNational Institute on Aging · USUCLA Health · USUniversity of California, Los Angeles · US
Funding
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4MEpigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0MEpigenetic Age as a Marker of Reproductive Age and Modifier of Invasive Breast Cancer Risk Among Postmenopausal WomenK07CA225856 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI BINDER, ALEXANDRA MARGARET LYNN · 2018 to 2020
$468kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–Biotechnology and Biological Sciences Research Council BB/W008793/1Medical Research Council MR/M01311/1Medical Research Council MR/M013111/1NCI NIH HHS K07 CA225856NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS N01 HC025195NIA NIH HHS U01 AG060908NIEHS NIH HHS R01 ES020836NIMHD NIH HHS HHSN268201800013IWellcome TrustWellcome Trust 221890/Z/20/Z
Abstract
We previously described a DNA methylation (DNAm) based biomarker of human mortality risk
Indexed as
Diabetes Mellitus, Type 2Metabolic SyndromeAgedAged, 80 and overAgingBiomarkersDNA MethylationEpigenesis, GeneticHumansBiomarkersDNA methylationepigenetic clockhealthspanmortality
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.