Evidence map›Paper›PMID 36516396›Full record

ArticleSchizophrenia bulletin2023

Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome.

Emily J Hird, Noriyuki Ohmuro, Paul Allen, Peter Moseley, Matthew J Kempton, Gemma Modinos, Gabriele Sachs, Mark van der Gaag, Lieuwe de Haan, Ary Gadelha and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 14 institutions in 12 countries.

Emily J HirdDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-6599-7292
Noriyuki OhmuroDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paul AllenDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Peter MoseleyPsychology Department, Northumbria University, College Lane, Newcastle-Upon-Tyne, NE1 8ST, UK.ORCID 0000-0002-9284-2509
Matthew J KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Gemma ModinosDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-7870-066X
Gabriele SachsDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8359-9877
Mark van der GaagFaculty of Behavioural and Movement Sciences, Department of Clinical Psychology, VU University, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.
Lieuwe de HaanDepartment Early Psychosis, AMC, Academic Psychiatric Centre, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands.
Ary GadelhaLiNC - Lab Interdisciplinar Neurociências Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
Rodrigo BressanLiNC - Lab Interdisciplinar Neurociências Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
Neus Barrantes-VidalDepartament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona), Fundació Sanitària Sant Pere Claver (Spain), Spanish Mental Health Research Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0002-8671-1238
Stephan RuhrmannDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Ana CatalanDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-0418-7904
EU-GEI High Risk Study
Philip McGuireDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
King's College London · GBUniversidade Federal de São Paulo · BRUniversitat Autònoma de Barcelona · ESThe University of Melbourne · AUUniversity of Copenhagen · DKCentre National de la Recherche Scientifique · FRUniversity of Cologne · DEParnassia Groep · NLMaastricht University Medical Centre · NLMedical University of Vienna · ATArkin · NLIcahn School of Medicine at Mount Sinai · USNorthumbria University · GBUniversity of the Basque Country · ES

Funding

Medical Research Council MR/J008915/1Medical Research Council MR/N026063/1
6 · The paper itself

Abstract

background and hypothesisAround 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes. STUDY

designAt baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning. STUDY

resultsCHR participants had a lower sensitivity to the task. Logistic regression revealed that a bias towards hearing targets in stimuli was associated with remission status (OR = 0.21, P = 042). Conversely, hearing SIs with uncertain valence at baseline was associated with reduced likelihood of remission (OR = 7.72. P = .007). When we assessed only participants who did not take antipsychotic medication at baseline, the association between hearing SIs with uncertain valence at baseline and remission likelihood remained (OR = 7.61, P = .043) and this variable was additionally associated with a greater likelihood of transition to psychosis (OR = 5.34, P = .029).

conclusionsIn CHR individuals, a tendency to hear speech in noise, and uncertainty about the affective valence of this speech, is associated with adverse outcomes. This task could be used in a battery of cognitive markers to stratify CHR participants according to subsequent outcomes.

Indexed as

Antipsychotic AgentsIllusionsPsychotic DisordersHumansIncidenceSpeechAntipsychotic Agentsremissionsignal-detectiontransitionuncertaintywhite noise task

Identifiers

PMID36516396
PMCPMC10016413
OpenAlexW4311452737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.