Evidence map›Paper›PMID 36516264›Full record

ArticleScience advances2022

A gating lever and molecular logic gate that couple voltage and calcium sensor activation to opening in BK potassium channels.

Liang Sun, Frank T Horrigan

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Fifty years of gating currents and channel gating.The Journal of general physiology · 2023
    Review
  11. Article
  12. E-cigarette aerosols of propylene glycol impair BK channel activity and parameters of mucociliary function.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Liang SunDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7817-5121
Frank T HorriganDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-6703-9581

Funding

Pore Gating Mechanisms of BK ChannelsR01GM127332 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ALDRICH, RICHARD, HORRIGAN, FRANK T · 2018 to 2021
$1.7M
NIGMS NIH HHS R01 GM127332
6 · The paper itself

Abstract

BK channels uniquely integrate voltage and calcium signaling in diverse cell types through allosteric activation of their K

Identifiers

PMID36516264
PMCPMC9750137

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.