ArticleScience advances2022
Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Longitudinal changes in control energy of brain networks in older adults at familial risk for Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- State-dependent signal flow hierarchy in the human cerebral cortex.Nature neuroscience · 2026Article
- Hierarchical Flows of Human Cortical Activity.bioRxiv : the preprint server for biology · 2026Article
- Controlling the human connectome with spatially diffuse input signals.Communications biology · 2026Article
- Optimal stochastic tracking control for brain network dynamics.Communications biology · 2025Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
- Connectome-constrained ligand-receptor interaction analysis for understanding brain network communication.Nature communications · 2025Article
- Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience.Communications biology · 2025Article
- Exploring Brain Size Asymmetry and Its Relationship with Predation Risk Among Chinese Anurans.Biology · 2025Article
- The possibilities of conscious experience in light of the dual origin hypothesis of the neocortex.Neuroscience of consciousness · 2025Article
- Unveiling the dynamic effects of major depressive disorder and its rTMS interventions through energy landscape analysis.Frontiers in neuroscience · 2025Article
- The control costs of human brain dynamics.Network neuroscience (Cambridge, Mass.) · 2025Article
- Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states.NeuroImage. Clinical · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Analyzing the brain's dynamic response to targeted stimulation using generative modeling.Network neuroscience (Cambridge, Mass.) · 2025Review
- A network control theory pipeline for studying the dynamics of the structural connectome.Nature protocols · 2024Article
- Shaping dynamical neural computations using spatiotemporal constraints.Biochemical and biophysical research communications · 2024Review
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies.Nature biomedical engineering · 2024Article
- Age-related differences in network controllability are mitigated by redundancy in large-scale brain networks.Communications biology · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Cortical variations in cytoarchitecture form a sensory-fugal axis that shapes regional profiles of extrinsic connectivity and is thought to guide signal propagation and integration across the cortical hierarchy. While neuroimaging work has shown that this axis constrains local properties of the human connectome, it remains unclear whether it also shapes the asymmetric signaling that arises from higher-order topology. Here, we used network control theory to examine the amount of energy required to propagate dynamics across the sensory-fugal axis. Our results revealed an asymmetry in this energy, indicating that bottom-up transitions were easier to complete compared to top-down. Supporting analyses demonstrated that asymmetries were underpinned by a connectome topology that is wired to support efficient bottom-up signaling. Lastly, we found that asymmetries correlated with differences in communicability and intrinsic neuronal time scales and lessened throughout youth. Our results show that cortical variation in cytoarchitecture may guide the formation of macroscopic connectome topology.
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