Evidence map›Paper›PMID 36516115›Full record

ArticlePLoS biology2022

Alzheimer's-related brain damage shows sex-specific links with risk factors.

Laurel A Beckett

Abstract readComment
In one paragraph

Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Laurel A BeckettDepartment of Public Health Sciences, School of Medicine, University of California, Davis, California, United States of America.ORCID 0000-0002-2418-9843

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
The Neuropathologic Landscape of Alzheimer's Disease in Hispanic DecedentsR01AG062517 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Brittany Nicole Dugger · 2019 to 2026
$10.5M
NIA NIH HHS R01 AG062517NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. A new study in PLOS Biology shows sex differences in the patterns of damage and in their association with risk and protective factors.

Indexed as

Alzheimer DiseaseBrain InjuriesAllelesApolipoproteins EBrainFemaleHumansMaleRisk FactorsSex Characteristicstau ProteinsApolipoproteins Etau Proteins

Identifiers

PMID36516115
PMCPMC9749968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.