ArticleEnvironmental health perspectives2022
Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children's Study (JECS).
Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association of maternal exposure to trace elements and toxic metals with repeated measurements of foetal and early-childhood growth: a systematic review.Occupational and environmental medicine · 2025Pooled it
- Prenatal exposure to essential and toxic elements in relation to infant growth trajectories.Environmental health : a global access science source · 2026Article
- The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study.BMC pediatrics · 2025Article
- Association between Maternal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Growth Trajectories up to 4 Years of Age: The Japan Environment and Children's Study.Environmental science & technology · 2025Article
- Japanese growth charts stratified by birth weight in 500-gram increments: Findings from the Japan Environment and Children's Study.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2025Article
- Impact of maternal body mass index and gestational comorbidities on the birth prevalence of orofacial clefts in the Japan Environment and Children's Study.Environmental health and preventive medicine · 2025Article
- Article
- A scoping review of dietary assessment questionnaires potentially suitable for assessing habitual dietary intake in the National Health and Nutrition Survey, Japan.Journal of nutritional science · 2024Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo our knowledge, the association of maternal exposure to metallic elements with weight trajectory pattern from the neonatal period has not been investigated.
objectivesThe goals of this study were to identify infant growth trajectories in weight in the first 3 y of life and to determine the associations of maternal blood levels of lead, cadmium, mercury, selenium, and manganese with growth trajectory.
methodsThis longitudinal study, part of the Japan Environment and Children Study, enrolled 103,099 pregnant women at 15 Regional Centres across Japan between 2011 and 2014. Lead, cadmium, mercury, selenium, and manganese levels were measured in blood samples collected in the second (14-27 wk gestational age) or third trimester (
resultsWe identified 5 trajectory patterns based on weight SD score: 4.74% of infants were classified in Group I, very small to small; 31.26% in Group II, moderately small; 21.91% in Group III, moderately small to moderately large; 28.06% in Group IV, moderately large to normal; and 14.03% in Group V, moderately large to large. On multinomial logistic regression, higher maternal lead and selenium levels tended to be associated with increased odds ratios (ORs) of poor weight SD score trajectories (Groups I and II), in comparison with Group III. Higher levels of mercury were associated with decreased ORs, whereas higher levels of manganese were associated with increased ORs of "moderately large" trajectories (Groups IV and V). DISCUSSION: Maternal lead, mercury, selenium, and manganese blood levels affect infant growth trajectory pattern in the first 3 y of life. https://doi.org/10.1289/EHP10321.
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