Evidence map›Paper›PMID 36515857›Full record

ArticleMolecular neurobiology2023

Blockade of Type 2A Protein Phosphatase Signaling Attenuates Complement C1q-Mediated Microglial Phagocytosis of Glutamatergic Synapses Induced by Amyloid Fibrils.

Jiang Wu, Jijun Xu, Mohamed Naguib, Bihua Bie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiang WuAnesthesiology Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Jijun XuDepartment of Pain Management, Anesthesiology Institute, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Mohamed NaguibAnesthesiology Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Bihua BieAnesthesiology Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. bieb@ccf.org.ORCID http://orcid.org/0000-0002-5497-2257
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Complement in Paclitaxel-induced peripheral neuropathyK08CA228039 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI XU, JIJUN · 2020 to 2024
$1.2M
COMPLEMENT C1q MEDIATES THE MICROGLIAL ELIMINATION OF SYNAPSES INDUCED BY AMYLOIDR56AG051594 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGUIB, MOHAMED · 2017 to 2017
$400k
NCI NIH HHS K08 CA228039NIA NIH HHS R56 AG051594
6 · The paper itself

Abstract

We previously reported the critical involvement of metabotropic GluR1 (mGluR1) signaling in complement C1q-dependent microglial phagocytosis of glutamatergic synapses in a rat model of Alzheimer's disease (AD) injected with amyloid fibrils. Here, we explored the role of type 2A protein phosphatase (type 2A PPase), a key enzyme downstream of mGluR1 signaling, in the pathogenesis of AD in rats. Significant local upregulation of PP2A expression was observed in the hippocampal CA1 after bilateral microinjection of amyloid-beta (Aβ

Indexed as

Alzheimer DiseaseComplement C1qAmyloidAmyloid beta-PeptidesAnimalsMicrogliaPhagocytosisRatsSynapsesAmyloidAmyloid beta-PeptidesComplement C1qAmyloid fibrilsComplement C1qMicroglial phagocytosisProtein phosphatase 2A

Identifiers

PMID36515857
PMCPMC9910161
OpenAlexW4311359308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.