Evidence map›Paper›PMID 36515809›Full record

ArticleJournal of cardiovascular translational research2023

Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes.

Veraprapas Kittipibul, Dmitry M Yaranov, John L Jefferies, Marc A Silver, Daniel Burkhoff, Vishal N Rao, Jan Biegus, Piotr Ponikowski, Marat Fudim

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The Impact of Obesity on Pressure-Volume Relationship in Ambulatory Heart Failure.Journal of cardiovascular translational research · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veraprapas KittipibulDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Dmitry M YaranovDepartment of Cardiology, Baptist Memorial Hospital, Memphis, TN, USA.
John L JefferiesThe Cardiovascular Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
Marc A SilverChicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.
Daniel BurkhoffCardiovascular Research Foundation, New York, NY, USA.
Vishal N RaoDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Jan BiegusInstitute of Heart Diseases, Medical University, Wroclaw, Poland.
Piotr PonikowskiInstitute of Heart Diseases, Medical University, Wroclaw, Poland.
Marat FudimDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. marat.fudim@duke.edu.ORCID 0000-0002-8671-7007

Funding

Congestion Phenotypes and Splanchnic Nerve Modulation in Chronic Heart FailureK23HL151744 · NHLBI · DUKE UNIVERSITY · PI FUDIM, MARAT · 2021 to 2022
$376k
NHLBI NIH HHS K23 HL151744
6 · The paper itself

Abstract

Studies have shown poor correlation between intra-cardiac pressures and blood volume (BV) measurements including HF. The impact of sex and left ventricular ejection fraction (LVEF) on this relationship has not been studied. We obtained pressure (pulmonary artery diastolic pressure (PADP)) and volume (total blood volume (TBV) and estimated stress blood volume (eSBV)) measurements from HF patients at the time of CardioMEMS implantation. A total of 20 patients were included. There was no significant difference between PADP, TBV, and eSBV between sexes. There was only a moderate correlation between PADP and eSBV in men but not in women or with TBV in both sexes. HFrEF had higher PADP and eSBV than HFpEF. There was a consistent lack of correlation between PADP and both TBV and eSBV. Further studies evaluating mid- to long-term implications of pressure-volume profiles as well as changes following decongestion therapy are warranted to better understand the pressure-volume interplay and determine appropriate decongestion strategy for each pressure-volume phenotype.

Indexed as

Heart FailureBlood VolumeFemaleHumansMalePhenylacetatesPrognosisStroke VolumeVentricular Function, LeftPhenylacetatesphenylacetic dipalmitateBlood volume analysisCardioMEMSHeart failure

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.