Evidence map›Paper›PMID 36515774›Full record

ArticlePrevention science : the official journal of the Society for Prevention Research2023

A Polygenic Risk Score Enhances Risk Prediction for Adolescents' Antisocial Behavior over the Combined Effect of 22 Extra-familial, Familial, and Individual Risk Factors in the Context of the Family Check-Up.

Frances L Wang, Kaitlin E Bountress, Kathryn Lemery-Chalfant, Melvin N Wilson, Daniel S Shaw

Open access · greenAbstract read
In one paragraph

Article in Prevention science : the official journal of the Society for Prevention Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Perceived Social Connectedness and Substance Use among Adolescents and Young Adults in North Carolina.Prevention science : the official journal of the Society for Prevention Research · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Frances L WangDepartment of Psychiatry, University of Pittsburgh, 3811 O'Hara St, Pittsburgh, PA, 15213, USA. wangfl@upmc.edu.ORCID 0000-0001-6548-0031
Kaitlin E BountressVirginia Commonwealth University, Richmond, USA.
Kathryn Lemery-ChalfantArizona State University, Tempe, USA.
Melvin N WilsonUniversity of Virginia, Charlottesville, USA.
Daniel S ShawUniversity of Pittsburgh, Pittsburgh, USA.
University of Pittsburgh · USArizona State University · USUniversity of Virginia · USVirginia Commonwealth University · US

Funding

Preventing Substance Use in the Context of Poverty: Risk and Protection from Early Childhood to Early AdulthoodR01DA036832 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, DANIEL S · 2014 to 2020
$10.2M
Parental Involvement, Extra-Familial Contexts and Prevention of Drug Use Risk.R01DA023245 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, DANIEL S · 2007 to 2011
$4.0M
Parent-Child Interaction Dynamics Mediate Genetic and Prevention Effects on the Development of Adolescent Substance Use DisordersR01DA053740 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LEMERY-CHALFANT, KATHRYN, TEIN, JENN-YUN · 2022 to 2025
$1.9M
The development of genetically-based pathways underlying problematic alcohol use - SupplementK01AA027757 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, FRANCES L · 2020 to 2024
$908k
Alcohol Use Phenotypes and Posttraumatic Stress Disorder: Investigating Shared Genetic, Behavioral, and Psychophysiological Risk FactorsK01AA028058 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOUNTRESS, KAITLIN ELIZABETH · 2020 to 2024
$876k
DEVELOPMENTAL EFFECTS OF PRENATAL CANNABINOID EXPOSURER15DA010368 · NIDA · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI MURPHY, LAURA L · 1996 to 1996
–
NIAAA NIH HHS K01 AA027757NIAAA NIH HHS K01 AA028058NIDA NIH HHS R01 DA023245NIDA NIH HHS R01 DA036832
6 · The paper itself

Abstract

Possessing informative tools to predict who is most at risk for antisocial behavior in adolescence is important to help identify families most in need of early intervention. Polygenic risk scores (PRSs) have been shown to predict antisocial behavior, but it remains unclear whether PRSs provide additional benefit above more conventional tools to early risk detection for antisocial behavior. This study examined the utility of a PRS in predicting adolescents' antisocial behavior after accounting for a broad index of children's contextual and individual risk factors for antisocial behavior. Participants were drawn from a longitudinal family-based prevention study (N = 463; N

Indexed as

Antisocial Personality DisorderGenome-Wide Association StudyAdolescentChildChild, PreschoolFemaleHumansInfantMaleMultifactorial InheritanceRisk FactorsAntisocial behaviorFamily Check-upPolygenic risk scorePrevention screening

Identifiers

PMID36515774
PMCPMC10226895
OpenAlexW4311479597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.