Evidence map›Paper›PMID 36515672›Full record

ArticleBJS open2022

Increased risk of type 3c diabetes mellitus after acute pancreatitis warrants a personalized approach including diabetes screening.

Alexander Walker, James O'Kelly, Catriona Graham, Sian Nowell, Doug Kidd, Damian J Mole

Open access · goldAbstract read
In one paragraph

Article in BJS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Risk Factors and Mechanisms for Diabetes in Pancreatitis.Gastroenterology clinics of North America · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Alexander WalkerMRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
James O'KellyMRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
Catriona GrahamEdinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK.
Sian NowelleData Research & Innovation Service (eDRIS), formerly Information Services Division, NHS National Services Scotland now part of Public Health Scotland, Edinburgh, Scotland, UK.
Doug KiddeData Research & Innovation Service (eDRIS), formerly Information Services Division, NHS National Services Scotland now part of Public Health Scotland, Edinburgh, Scotland, UK.
Damian J MoleMRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-6884-7302
Centre for Inflammation Research · GBNational Health Service Scotland · GBEdinburgh Royal Infirmary · GBUniversity of Edinburgh · GB

Funding

Medical Research Council MR/P008887/1UKRI Medical Research CouncilWellcome Trust
6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP) is a frequent cause of hospitalization with long-term health consequences, including type 3c diabetes mellitus (DM). The incidence and risk factors for new-onset morbidities after AP need to be clarified to inform a personalized medicine approach.

methodsUsing a longitudinal electronic healthcare record-linkage analysis, all patients admitted to hospital in Scotland with a first episode of AP between 1 April 2009 and 31 March 2012 and followed for a minimum of 5 years after their index AP admission were identified. All new-onset morbidity with specific focus on type 3c DM were analysed and, using time-split multiple regression.

resultsA total of 2047 patients were included. AP requiring critical care was followed by 2 years of heightened risk (HR 5.24) of developing type 3c DM, increased risk of new-onset cardiac disease (HR 1.61), and renal disease (HR 2.96). The additional risk conferred by critical care AP had a negative interaction with time, whereas additional risk associated with male sex and a non-gallstone aetiology was long lasting.

conclusionBased on these findings, a personalized approach to include type 3c DM screening for a minimum of 2 years for individuals who required critical care when hospitalized with AP is recommended.

Indexed as

Diabetes MellitusPancreatitisAcute DiseaseHumansIncidenceMaleRisk Factors

Identifiers

PMID36515672
PMCPMC9749482
OpenAlexW4311463150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.