Evidence map›Paper›PMID 36515266›Full record

ArticleeLife2022

Piezo1 as a force-through-membrane sensor in red blood cells.

George Vaisey, Priyam Banerjee, Alison J North, Christoph A Haselwandter, Roderick MacKinnon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Spatial Deconstruction of the Plasma Membrane.Journal of the American Chemical Society · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway.Cellular and molecular life sciences : CMLS · 2025
    Article
  13. Article
  14. Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

George VaiseyLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.ORCID 0000-0002-8359-1314
Priyam BanerjeeBio-Imaging Resource Center, The Rockefeller University, New York, United States.
Alison J NorthBio-Imaging Resource Center, The Rockefeller University, New York, United States.
Christoph A HaselwandterDepartment of Physics and Astronomy and Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, United States.ORCID 0000-0002-5012-5640
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.ORCID 0000-0001-7605-4679
Howard Hughes Medical Institute · USRockefeller University · USUniversity of Southern California · US

Funding

Voltage-Dependent Ion Channel GatingR01GM043949 · NIGMS · ROCKEFELLER UNIVERSITY · PI MACKINNON, RODERICK · 1990 to 2024
$10.1M
Acquisition of a DeltaVision OMX SR 3D SIM system for super-resolution imagingS10RR031855 · NCRR · ROCKEFELLER UNIVERSITY · PI NORTH, ALISON JANE · 2011 to 2011
$600k
NCRR NIH HHS S10 RR031855NCRR NIH HHS S10RR031855NIGMS NIH HHS R01 GM043949NIH HHS GM043949
6 · The paper itself

Abstract

Piezo1 is the stretch activated Ca

Indexed as

ErythrocytesIon ChannelsErythrocyte MembraneMechanical PhenomenaMechanotransduction, CellularMembranesIon Channelsmechanosensationmolecular biophysicsmousephysics of living systemspiezored blood cellsstructural biologysuper-resolution microscopy

Identifiers

PMID36515266
PMCPMC9750178
OpenAlexW4311392382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.