ArticleeLife2022
A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- There are more things in heaven and Earth than we dream of in our physiology.The Journal of physiology · 2026Article
- Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging.GeroScience · 2026Article
- Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025Article
- Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025Review
- Heart Rhythm Harmony Becomes Discordant as We Age.Heart, lung & circulation · 2025Review
- Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues.Frontiers in bioengineering and biotechnology · 2025Article
- The Nrf Family and Its Cardioprotective Potential: Mechanisms, Functions, and Therapeutic Perspectives.Drug design, development and therapy · 2025Review
- RelA-mediated signaling connects adaptation to chronic cardiomyocyte stress with myocardial and systemic inflammation in the ADCY8 model of accelerated aging.GeroScience · 2024Article
- Spermidine Exerts Protective Effects in Random-Pattern Skin Flap Survival in Rats: Possible Involvement of Inflammatory Cytokines, Nitric Oxide, and VEGF.Aesthetic plastic surgery · 2024Article
- Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Article
- Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles.Frontiers in pharmacology · 2024Review
- Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication.JACC. Clinical electrophysiology · 2023Article
- Musings on intrinsic cardiomyocyte cell cycle activity and myocardial regeneration.Journal of molecular and cellular cardiology · 2023Review
- Article
- Article
- Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice.Fortune journal of health sciences · 2023Article
- A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
38 authors at 3 institutions in 1 country.
Kirill V TarasovLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.ORCID 0000-0001-7799-4670
Khalid ChakirLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Daniel R RiordonLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Alexey E LyashkovTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Ismayil AhmetLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Maria Grazia PerinoLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Allwin Jennifa SilvesterLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Jing ZhangLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Mingyi WangLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Yevgeniya O LukyanenkoTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Jia-Hua QuLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Miguel Calvo-Rubio BarreraTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Magdalena JuhaszovaLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Yelena S TarasovaLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Bruce ZimanLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Richard TelljohannLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Vikas KumarLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Mark RanekDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.
John LammonsLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Rostislav BychkovLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Rafael de CaboTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States.ORCID 0000-0003-2830-5693
Seungho JunDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.
Gizem KeceliDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-9562-7994
Ashish GuptaDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.
Dongmei YangLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Miguel A AonLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Luigi AdamoDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.
Christopher H MorrellLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Walter OtuLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Cameron CarrollLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Shane ChambersLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Nazareno PaolocciDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.
Thanh HuynhSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Robert WeissDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States.
Loren FieldKraennert Institute of Cardiology, Indiana University School of Medicine, Idianapolis, United States.
Steven J SollottLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.
Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, United States.ORCID 0000-0002-4772-0035
National Institutes of Health · USJohns Hopkins University · USIndiana University School of Medicine
Funding
CONTRIBUTION OF ENERGY DEPLETION TO HUMAN HEART FAILURER01HL061912 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 1999 to 2020
$8.0MIN VIVO MURINE CARDIAC ENERGY METABOLISM AND FUNCTIONR01HL063030 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2000 to 2018
$4.9MThe Hemodynamic and Metabolic Effects of Advanced Circulatory Support for ResuscitationR01HL155760 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2021 to 2024
$3.2MBDNF TrkB- and beta-AR signals in ischemic and non-ischemic cardiomyopathyR01HL136918 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PAOLOCCI, NAZARENO · 2018 to 2021
$2.7MSequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following InjuryR01HL155218 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIELD, LOREN J · 2021 to 2024
$2.0MBIOMECHANICAL FACTORS IN CONGENITAL VASCULAR DISEASER01HL115560 · NHLBI · WASHINGTON UNIVERSITY · PI WAGENSEIL, JESSICA · 2012 to 2015
$1.5MNHLBI NIH HHS R01 HL061912NHLBI NIH HHS R01 HL063030NHLBI NIH HHS R01 HL115560NHLBI NIH HHS R01 HL136918NHLBI NIH HHS R01 HL155218NHLBI NIH HHS R01 HL155760
Abstract
Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TG
Indexed as
Adaptation, PhysiologicalMyocytes, CardiacStress, PhysiologicalAdenylyl CyclasesAnimalsHeart FailureHeart VentriclesHumansHypertrophyMiceMice, Transgenicadenylyl cyclase 8Adenylyl Cyclasesautophagycardiac overexpression of human ADCY8cell biologyleft ventriclemousenutrient sensingproliferationprotection from apoptosisprotein synthesisproteomeproteosome 35 activityROS scavengingtranscriptome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.