Evidence map›Paper›PMID 36515253›Full record

ArticleJournal of the American Heart Association2022

Utility of the ACC/AHA Lesion Classification to Predict Outcomes After Contemporary DES Treatment: Individual Patient Data Pooled Analysis From 7 Randomized Trials.

Maayan Konigstein, Björn Redfors, Zixuan Zhang, Lak N Kotinkaduwa, Gary S Mintz, Pieter C Smits, Patrick W Serruys, Clemens von Birgelen, Mahesh V Madhavan, Mordechai Golomb and 4 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Comparison of Immediate Versus Staged Complete Revascularization in Patients With Index PCI Coronary Complications: A Study on Clinical Outcomes and Predictors of Complications.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Trial
  3. Interaction between coronary lesion complexity and coronary microvascular dysfunction in the prognosis of NSTEMI patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
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  8. One-year outcome of robotical vs. manual percutaneous coronary intervention.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  9. Article
  10. Predilation in Primary Percutaneous Coronary Intervention.Interventional cardiology (London, England) · 2025
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maayan KonigsteinClinical Trials Center Cardiovascular Research Foundation New York NY.ORCID 0000-0002-9398-471X
Björn RedforsClinical Trials Center Cardiovascular Research Foundation New York NY.ORCID 0000-0002-4155-4451
Zixuan ZhangClinical Trials Center Cardiovascular Research Foundation New York NY.
Lak N KotinkaduwaClinical Trials Center Cardiovascular Research Foundation New York NY.
Gary S MintzClinical Trials Center Cardiovascular Research Foundation New York NY.ORCID 0000-0003-3296-8705
Pieter C SmitsMaasstad Ziekenhuis Rotterdam The Netherlands.ORCID 0000-0002-9164-720X
Patrick W SerruysImperial College of Science, Technology and Medicine London United Kingdom.ORCID 0000-0002-9636-1104
Clemens von BirgelenDepartment of Cardiology Thoraxcentrum Twente, Medisch Spectrum Twente Enschede The Netherlands.ORCID 0000-0002-5128-2832
Mahesh V MadhavanClinical Trials Center Cardiovascular Research Foundation New York NY.ORCID 0000-0002-7740-1481
Mordechai GolombClinical Trials Center Cardiovascular Research Foundation New York NY.
Ori Ben-YehudaClinical Trials Center Cardiovascular Research Foundation New York NY.ORCID 0000-0001-9199-1660
Roxana MehranClinical Trials Center Cardiovascular Research Foundation New York NY.ORCID 0000-0002-5546-262X
Martin B LeonClinical Trials Center Cardiovascular Research Foundation New York NY.
Gregg W StoneUniversity of California - San Diego Health - La Jolla and Hillcrest Hospitals San Diego CA.ORCID 0000-0002-3416-8210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Use of the modified American College of Cardiology (ACC)/American Heart Association (AHA) lesion classification as a prognostic tool to predict short- and long-term clinical outcomes after percutaneous coronary intervention in the modern drug-eluting stent era is uncertain. Methods and Results Patient-level data from 7 prospective, randomized trials were pooled. Clinical outcomes of patients undergoing single lesion percutaneous coronary intervention with second-generation drug-eluting stent were analyzed according to modified ACC/AHA lesion class. The primary end point was target lesion failure (TLF: composite of cardiac death, target vessel myocardial infarction, or ischemia-driven target lesion revascularization). Clinical outcomes to 5 years were compared between patients treated for noncomplex (class A/B1) versus complex (class B2/C) lesions. Eight thousand five hundred sixteen patients (age 63.1±10.8 years, 70.5% male) were analyzed. Lesions were classified as A, B1, B2, and C in 7.9%, 28.5%, 33.7%, and 30.0% of cases, respectively. Target lesion failure was higher in patients undergoing percutaneous coronary intervention of complex versus noncomplex lesions at 30 days (2.0% versus 1.1%,

Indexed as

CardiologyCoronary Artery DiseaseDrug-Eluting StentsMyocardial InfarctionPercutaneous Coronary InterventionAgedFemaleHumansMaleMiddle AgedProspective StudiesProsthesis DesignRandomized Controlled Trials as TopicRisk FactorsTreatment Outcomedrug‐eluting stentspercutaneous coronary interventiontarget lesion failure

Identifiers

PMID36515253
PMCPMC9798816

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.