Evidence map›Paper›PMID 36515245›Full record

ArticleJournal of the American Heart Association2022

SerpinG1: A Novel Biomarker Associated With Poor Coronary Collateral in Patients With Stable Coronary Disease and Chronic Total Occlusion.

Shuai Chen, Le-Ying Li, Zhi-Ming Wu, Yong Liu, Fei-Fei Li, Ke Huang, Yi-Xuan Wang, Qiu-Jing Chen, Xiao-Qun Wang, Wei-Feng Shen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  14. Human serum proteomics reveals a molecular signature after one night of sleep deprivation.Sleep advances : a journal of the Sleep Research Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Shuai ChenDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Le-Ying LiDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Zhi-Ming WuDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Yong LiuDepartment of Nursing, Chongqing Medical and Pharmaceutical College Chongqing China.
Fei-Fei LiDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Ke HuangDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Yi-Xuan WangDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Qiu-Jing ChenInstitute of Cardiovascular Diseases Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0002-5668-3774
Xiao-Qun WangDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0003-0956-8041
Wei-Feng ShenDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Rui-Yan ZhangDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Ying ShenInstitute of Cardiovascular Diseases Shanghai Jiaotong University School of Medicine Shanghai China.
Lin LuDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0003-0145-8008
Feng-Hua DingDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0001-9507-4704
Yang DaiDepartment of Vascular and Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0003-4365-4875
Shanghai Jiao Tong University · CNRuijin Hospital · CNChongqing Medical and Pharmaceutical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background This study aimed to explore predictive biomarkers of coronary collateralization in patients with chronic total occlusion. Methods and Results By using a microarray expression profiling program downloaded from the Gene Expression Omnibus database, weighted gene coexpression network analysis was constructed to analyze the relationship between potential modules and coronary collateralization and screen out the hub genes. Then, the hub gene was identified and validated in an independent cohort of patients (including 299 patients with good arteriogenic responders and 223 patients with poor arteriogenic responders). Weighted gene coexpression network analysis showed that

Indexed as

Complement C1 Inhibitor ProteinCoronary Artery DiseaseCoronary OcclusionBiomarkersCollateral CirculationGene Regulatory NetworksHumansBiomarkersComplement C1 Inhibitor ProteinSERPING1 protein, humanchronic total occlusioncoronary artery diseasecoronary collateralizationweighted gene coexpression network analysis

Identifiers

PMID36515245
PMCPMC9798810
OpenAlexW4311477763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.