Evidence map›Paper›PMID 36515150›Full record

SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023

Management of REM sleep behavior disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.

Michael Howell, Alon Y Avidan, Nancy Foldvary-Schaefer, Roneil G Malkani, Emmanuel H During, Joshua P Roland, Stuart J McCarter, Rochelle S Zak, Gerard Carandang, Uzma Kazmi and 1 more

Open access · bronzeAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Guideline
  2. Review
  3. Article
  4. The use of cannabinoid therapy in treatment-refractory isolated REM sleep behavior disorder: a case report.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. REM Behavior Disorder: Implications for PD Therapeutics.Current neurology and neuroscience reports · 2023
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Michael HowellDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota.
Alon Y AvidanDavid Geffen School of Medicine at UCLA, Los Angeles, California.
Nancy Foldvary-SchaeferCleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
Roneil G MalkaniDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Emmanuel H DuringDepartment of Neurology, Division of Movement Disorders, Icahn School of Medicine at Mount Sinai, New York, New York.
Joshua P RolandThirty Madison, New York, New York.
Stuart J McCarterDepartment of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Rochelle S ZakSleep Disorders Center, University of California, San Francisco, San Francisco, California.
Gerard CarandangAmerican Academy of Sleep Medicine, Darien, Illinois.
Uzma KazmiAmerican Academy of Sleep Medicine, Darien, Illinois.
Kannan RamarDivision of Pulmonary and Critical Care Medicine, Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota.
American Academy of Sleep Medicine · USMayo Clinic · USUniversity of California, Los Angeles · USCleveland Clinic Lerner College of Medicine · USIcahn School of Medicine at Mount Sinai · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review provides supporting evidence for a clinical practice guideline for the management of rapid eye movement (REM) sleep behavior disorder in adults and children. The American Academy of Sleep Medicine commissioned a task force of 7 experts in sleep medicine. A systematic review was conducted to identify randomized controlled trials and observational studies that addressed interventions for the management of REM sleep behavior disorder in adults and children. Statistical analyses were performed to determine the clinical significance of critical and important outcomes. Finally, the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) process was used to assess the evidence for making recommendations. The literature search identified 4,690 studies; 148 studies provided data suitable for statistical analyses; evidence for 45 interventions is presented. The task force provided a detailed summary of the evidence assessing the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations. CITATION: Howell M, Avidan AY, Foldvary-Schaefer N, et al. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.

Indexed as

REM Sleep Behavior DisorderAcademies and InstitutesAdultChildGRADE ApproachHumansResearch DesignSleepUnited Statesdementia with Lewy bodiesdream enactmentnarcolepsyparasomniaParkinson’s diseaseREM sleepREM sleep behavior disordersleep disorder

Identifiers

PMID36515150
PMCPMC10071381
OpenAlexW4311327063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.