Evidence map›Paper›PMID 36515010›Full record

ArticleJournal of developmental origins of health and disease2023

Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood.

Ella Parsons, Sheryl L Rifas-Shiman, Anne K Bozack, Andrea A Baccarelli, Dawn L DeMeo, Marie-France Hivert, Lode Godderis, Radu-Corneliu Duca, Emily Oken, Andres Cardenas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of developmental origins of health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Ella ParsonsDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Anne K BozackDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0001-7752-2585
Lode GodderisIDEWE, External Service for Prevention and Protection at Work, Heverlee, Belgium.
Radu-Corneliu DucaCentre for Environment & Health, Department of Public Health & Primary Care, University of Leuven (KU Leuven), Leuven, Belgium.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0003-2513-3339
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA.ORCID 0000-0003-2284-3298
Harvard University · USBerkeley Public Health Division · USBrigham and Women's Hospital · USColumbia University · USEuropean External Action Service · BELaboratoire National de Santé · LUStanford University · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NICHD NIH HHS R01 HD034568NIEHS NIH HHS R01 ES031259NIEHS NIH HHS R24 ES030894NIH HHS UH3 OD023286
6 · The paper itself

Abstract

The prenatal environment may program health and disease susceptibility via epigenetic mechanisms. We evaluated associations of maternal trimester-specific intake of micronutrients with global DNA methylation (%5mC) and 5-hydroxymethylation (%5hmC) at birth in cord blood and tested for persistence into childhood. We quantified global %5mC and %5hmC in cord blood cells (

Indexed as

DNA MethylationMicronutrientsChild, PreschoolCholineFemaleFolic AcidHumansInfant, NewbornPregnancyVitaminsCholineFolic AcidMicronutrientsVitaminsDNA hydroxymethylationDNA methylationEpigenetics

Identifiers

PMID36515010
PMCPMC9998337
OpenAlexW4311377648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.