Evidence map›Paper›PMID 36514983›Full record

ArticleOpen biology2022

The evolutionary dynamics that retain long neutral genomic sequences in face of indel deletion bias: a model and its application to human introns.

Gil Loewenthal, Elya Wygoda, Natan Nagar, Lior Glick, Itay Mayrose, Tal Pupko

Abstract read
In one paragraph

Article in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gil LoewenthalThe Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 69978, Israel.
Elya WygodaThe Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 69978, Israel.
Natan NagarThe Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 69978, Israel.
Lior GlickSchool of Plant Sciences and Food Security, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Itay MayroseSchool of Plant Sciences and Food Security, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Tal PupkoThe Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0001-9463-2575

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insertions and deletions (indels) of short DNA segments are common evolutionary events. Numerous studies showed that deletions occur more often than insertions in both prokaryotes and eukaryotes. It raises the question why neutral sequences are not eradicated from the genome. We suggest that this is due to a phenomenon we term

Indexed as

Evolution, MolecularINDEL MutationGenomeGenomicsHumansIntronsborder-induced selectionc-value paradoxdeletion biasgenome evolutionindelintron

Identifiers

PMID36514983
PMCPMC9748784

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.