Evidence map›Paper›PMID 36514413›Full record

ArticleKidney3602022

Magnetic Resonance Elastography as Surrogate Marker of Interstitial Fibrosis in Kidney Transplantation: A Prospective Study.

Bertrand Chauveau, Pierre Merville, Bruno Soulabaille, Benjamin Taton, Hannah Kaminski, Jonathan Visentin, Agathe Vermorel, Mounir Bouzgarrou, Lionel Couzi, Nicolas Grenier

Registry-linked trialAbstract read
In one paragraph

Article in Kidney360, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03918161 (Magnetic Resonance Elastography of Transplanted Kidney), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03918161 nacompletednot on this map

Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)

TypeinterventionalSponsorUniversity Hospital, BordeauxRan2019 to 2020Enrolled73ConditionsInterstitial Fibrosis/Tubular Atrophy of Transplanted KidneysArmsMRE exam
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Bertrand ChauveauCHU de Bordeaux, Service de Pathologie, Hôpital Pellegrin, Place Amélie Raba Léon, Bordeaux, France.ORCID 0000-0002-3250-4604
Pierre MervilleUniversité de Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, Bordeaux, France.ORCID 0000-0001-8987-2929
Bruno SoulabailleCHU de Bordeaux, Service d'Imagerie Diagnostique et Interventionnelle de l'Adulte, Hôpital Pellegrin, France.ORCID 0000-0001-6283-8800
Benjamin TatonCHU de Bordeaux, Service de Néphrologie, Transplantation Dialyse, Aphérèses, Hôpital Pellegrin, Bordeaux, France.ORCID 0000-0001-9609-8652
Hannah KaminskiUniversité de Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, Bordeaux, France.ORCID 0000-0003-1604-3825
Jonathan VisentinUniversité de Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, Bordeaux, France.ORCID 0000-0003-3795-8979
Agathe VermorelCHU de Bordeaux, Service de Néphrologie, Transplantation Dialyse, Aphérèses, Hôpital Pellegrin, Bordeaux, France.ORCID 0000-0002-3261-3085
Mounir BouzgarrouCHU de Bordeaux, Service d'Imagerie Diagnostique et Interventionnelle de l'Adulte, Hôpital Pellegrin, France.
Lionel CouziUniversité de Bordeaux, CNRS, ImmunoConcEpT, UMR 5164, Bordeaux, France.ORCID 0000-0002-9213-6196
Nicolas GrenierCHU de Bordeaux, Service d'Imagerie Diagnostique et Interventionnelle de l'Adulte, Hôpital Pellegrin, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fibrosis progression is a major prognosis factor in kidney transplantation. Its assessment requires an allograft biopsy, which remains an invasive procedure at risk of complications. Methods: We assessed renal stiffness by magnetic resonance elastography (MRE) as a surrogate marker of fibrosis in a prospective cohort of kidney transplant recipients compared with the histologic gold standard. Interstitial fibrosis was evaluated by three methods: the semi-quantitative Banff ci score, a visual quantitative evaluation by a pathologist, and a computer-assisted quantitative evaluation. MRE-derived stiffness was assessed at the superior, median, and inferior poles of the allograft. Results: We initially enrolled 73 patients, but only 55 had measurements of their allograft stiffness by MRE before an allograft biopsy. There was no significant correlation between MRE-derived stiffness at the biopsy site and the ci score ( Conclusions: MRE-derived stiffness does not directly reflect the extent of fibrosis in kidney transplantation.

Indexed as

Elasticity Imaging TechniquesKidney TransplantationBiomarkersFibrosisHumansProspective StudiesBiomarkerselastographyfibrosishistopathologykidney transplantationmagnetic resonance imagingprospective studiestransplantation

Identifiers

PMID36514413
PMCPMC9717636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.