Evidence map›Paper›PMID 36514310›Full record

ArticleiScience2023

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.

Yaozong Chen, Jérémie Prévost, Irfan Ullah, Hugo Romero, Veronique Lisi, William D Tolbert, Jonathan R Grover, Shilei Ding, Shang Yu Gong, Guillaume Beaudoin-Bussières and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Yaozong ChenInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
Jérémie PrévostCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Irfan UllahDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Hugo RomeroCentre de Recherche du CHU Ste-Justine, Montreal, QC H3T 1C5, Canada.
Veronique LisiCentre de Recherche du CHU Ste-Justine, Montreal, QC H3T 1C5, Canada.
William D TolbertInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
Jonathan R GroverDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Shilei DingCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Shang Yu GongCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Guillaume Beaudoin-BussièresCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Romain GasserCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Mehdi BenlarbiCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Dani VézinaCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Sai Priya AnandCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Debashree ChatterjeeCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Guillaume GoyetteCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Michael W GrunstDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Ziwei YangDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Yuxia BoDepartment of Biochemistry, Microbiology and Immunology, Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Fei ZhouUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Kathie BélandCentre de Recherche du CHU Ste-Justine, Montreal, QC H3T 1C5, Canada.
Xiaoyun BaiLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Allison R ZeherUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Rick K HuangUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Dung N NguyenInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
Rebekah SherburnInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
Di WuBiophysics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Grzegorz PiszczekBiophysics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bastien ParéDépartement de Biochimie et Médecine Moléculaire, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Doreen MatthiesUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Di XiaLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jonathan RichardCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.
Priti KumarDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Walther MothesDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Marceline CôtéDepartment of Biochemistry, Microbiology and Immunology, Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Pradeep D UchilDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Vincent-Philippe LavalléeCentre de Recherche du CHU Ste-Justine, Montreal, QC H3T 1C5, Canada.
Martin A SmithCentre de Recherche du CHU Ste-Justine, Montreal, QC H3T 1C5, Canada.
Marzena PazgierInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.
Elie HaddadDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
Andrés FinziCentre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.

Funding

Towards high-resolution structural biology of membrane protein complexes in their native lipid environmentZIAHD008998 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MATTHIES, DOREEN · 2021 to 2025
$10.7M
Structure and Dynamics of the SARS-CoV-2 Spike ProteinR01AI163395 · NIAID · YALE UNIVERSITY · PI MOTHES, WALTHER H · 2021 to 2025
$4.1M
Predoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6M
Mechanism of Inhibition of Entry Inhibitors against SARS-CoVsZIABC011972 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI XIA, DI S · 2020 to 2023
$656k
NIAID NIH HHS R01 AI163395NIAID NIH HHS T32 AI055403
6 · The paper itself

Abstract

Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral mechanisms is crucial for developing vaccines and therapeutics against VOCs. Here we characterized two potent NAbs, EH3 and EH8, isolated from an unvaccinated pediatric patient with exceptional plasma neutralization activity. EH3 and EH8 cross-neutralize the early VOCs and mediate strong Fc-dependent effector activity

Indexed as

ImmunologyVirology

Identifiers

PMID36514310
PMCPMC9733284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.