Evidence map›Paper›PMID 36514134›Full record

SynthesisArthritis research & therapy2022

Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations.

Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M Mason, Stephen Burgess, Susanna C Larsson

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Arthritis research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Shuai Yuan *Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobelsväg 13, 17 177, Stockholm, Sweden.
Jie Chen *Centre for Global Health, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, China.
Xixian RuanDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, China.
Mathew VithayathilMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Siddhartha KarMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Xue LiDepartment of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Amy M MasonBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Susanna C LarssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobelsväg 13, 17 177, Stockholm, Sweden. susanna.larsson@ki.se.
University of Cambridge · GBKarolinska Institutet · SEMRC Cancer Unit · GBSecond Affiliated Hospital of Zhejiang University · CNThird Xiangya Hospital · CNUniversity of Bristol · GBUppsala University · SEZhejiang University · CN

Funding

ARACHIDONATE METABOLISM IN GLOMERULONEPHRITIS/VASCULITISK08HL001313 · NHLBI · WASHINGTON UNIVERSITY · PI LEFKOWITH, JAMES B · 1985 to 1988
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British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_PC_17228Medical Research Council MC_UU_00002/7Wellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

backgroundThe associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the associations of RA with site-specific cancers in European and East Asian populations.

methodsIndependent genetic variants strongly associated with RA in European and East Asian populations were selected as instrumental variables from genome-wide association studies of 58,284 European individuals (14,361 cases and 43,923 controls) and 22,515 East Asian individuals (4873 cases and 17,642 controls), respectively. The associations of genetic variants with overall and 22 site-specific cancers were extracted from the UK Biobank study (n = 367,561), the FinnGen study (n = 260,405), Biobank Japan (n = 212,453), and international consortia. The associations for one outcome from different data sources were combined by meta-analysis.

resultsIn the European population, the combined odds ratios per 1-unit increase in log odds of genetic liability to RA were 1.06 (95% confidence interval [CI] 1.03-1.10) for head and neck cancer, 1.06 (95% CI 1.02-1.10) for cervical cancer, 0.92 (95% CI 0.87-0.96) for testicular cancer, and 0.94 (95% CI 0.90-0.98) for multiple myeloma. In the East Asian population, the corresponding odds ratios were 1.17 (95% CI 1.06-1.29) for pancreatic cancer, 0.91 (95% CI 0.88-0.94) for breast cancer, and 0.90 (95% CI 0.84-0.96) for ovarian cancer. There were suggestive associations for breast and ovarian cancer and overall cancer in the European population. No other associations were observed.

conclusionThis study suggests that RA may play a role in the development of several site-specific cancers.

Indexed as

Arthritis, RheumatoidOvarian NeoplasmsTesticular NeoplasmsEast Asian PeopleEuropean PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideEast AsianEuropeanMendelian randomizationRheumatoid arthritis

Identifiers

PMID36514134
PMCPMC9746148
OpenAlexW4311225981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.