Evidence map›Paper›PMID 36514085›Full record

ArticleBMC endocrine disorders2022

Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women.

Mervat M El-Eshmawy, Asmaa Ibrahim, Rania Bahriz, Nermeen Shams-Eldin, Nancy Mahsoub

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mervat M El-EshmawyInternal Medicine Department, Mansoura Specialized Medical Hospital, Faculty of Medicine, Mansoura University, P.O. Box: 35516, Mansoura, Egypt. mervat2040@yahoo.com.
Asmaa IbrahimInternal Medicine Department, Meet Salsil Central Hospital, Ministry of Health and Population, Meet Salsil, Egypt.
Rania BahrizInternal Medicine Department, Mansoura Specialized Medical Hospital, Faculty of Medicine, Mansoura University, P.O. Box: 35516, Mansoura, Egypt.
Nermeen Shams-EldinGynecology and Obstetric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Nancy MahsoubClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mansoura University · EGMinistry of Health and Population · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFeatures of metabolic syndrome such as abdominal obesity, insulin resistance, hypertension and dyslipidemia are commonly encountered in polycystic ovary syndrome (PCOS). Recent evidence has suggested an association between high serum uric acid/creatinine (UA/Cr) ratio and metabolic syndrome however, no studies have investigated this association in PCOS. The current study was conducted to investigate the relationship between UA/Cr ratio and PCOS and to identify whether UA/Cr ratio and free androgen index (FAI) have an additive interaction for detection of PCOS risk in obese women.

methodsThis study enrolled 40 obese women with PCOS and 40 control women with regular menstrual cycles matched for age and body mass index (BMI). Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipids profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), total testosterone, free androgen index (FAI), UA/Cr ratio were assessed.

resultsSerum UA/Cr ratio was significantly higher in obese women with PCOS than in non-PCOS women. UA/Cr ratio was correlated with BMI, waist and neck circumferences, blood pressure, fasting insulin, HOMA-IR, lipids, LH/FSH, estradiol, DHEAS, total testosterone, FAI and SHBG. UA/Cr ratio and FAI were independent risk factors for PCOS in obese women however, the addictive interaction between UA/Cr ratio and FAI had a higher fold risk (OR: 4.3, 95% CI, 3.4-7.58) and a more significance (P = 0.002) for determination of PCOS.

conclusionSerum UA/Cr ratio combined with FAI can exert an additive or synergistic impact on prediction of PCOS in obese women.

Indexed as

Insulin ResistanceMetabolic SyndromePolycystic Ovary SyndromeAndrogensBlood GlucoseBody Mass IndexCreatinineEstradiolFemaleFollicle Stimulating HormoneHumansInsulinLipidsLuteinizing HormoneObesityTestosteroneAndrogensBlood GlucoseCreatinineEstradiolFollicle Stimulating HormoneInsulinLipidsLuteinizing HormoneTestosteroneUric AcidFree androgen indexPolycystic ovary syndromeSerum uric acid/creatinine ratio

Identifiers

PMID36514085
PMCPMC9746110
OpenAlexW4311361900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.