Evidence map›Paper›PMID 36513998›Full record

ArticleBMC medical research methodology2022

Methodology of the INVestigating traIning assoCiated blasT pAthology (INVICTA) study.

Michael J Roy, David O Keyser, Sheilah S Rowe, Rene S Hernandez, Marcia Dovel, Holland Romero, Diana Lee, Matthew Menezes, Elizabeth Magee, Danielle J Brooks and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical research methodology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Michael J RoyDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA. michael.roy@usuhs.edu.
David O KeyserDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Sheilah S RoweDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Rene S HernandezDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Marcia DovelDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Holland RomeroDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Diana LeeDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Matthew MenezesDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Elizabeth MageeDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Danielle J BrooksDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Chen LaiDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Jessica GillDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Suthee WiriApplied Research Associates, Albuquerque, NM, USA.
Elizabeth MetzgerDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
J Kent WernerDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Douglas BrungartWalter Reed National Military Medical Center, Bethesda, MD, USA.
Devon M KulinskiWalter Reed National Military Medical Center, Bethesda, MD, USA.
Dominic NathanDepartment of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.
Walter S CarrCenter for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Uniformed Services University of the Health Sciences · USCenter for Neuroscience and Regenerative Medicine · USHenry M. Jackson Foundation · USJackson Foundation · USWalter Reed National Military Medical Center · USApplied Research Associates (United States) · USWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubconcussive blast exposure during military training has been the subject of both anecdotal concerns and reports in the medical literature, but prior studies have often been small and have used inconsistent methods.

methodsThis paper presents the methodology employed in INVestigating traIning assoCiated blasT pAthology (INVICTA) to assess a wide range of aspects of brain function, including immediate and delayed recall, gait and balance, audiologic and oculomotor function, cerebral blood flow, brain electrical activity and neuroimaging and blood biomarkers.

resultsA number of the methods employed in INVICTA are relatively easy to reproducibly utilize, and can be completed efficiently, while other measures require greater technical expertise, take longer to complete, or may have logistical challenges.

conclusionsThis presentation of methods used to assess the impact of blast exposure on the brain is intended to facilitate greater uniformity of data collection in this setting, which would enable comparison between different types of blast exposure and environmental circumstances, as well as to facilitate meta-analyses and syntheses across studies.

Indexed as

Blast InjuriesBrain ConcussionMilitary PersonnelBiomarkersHumansBiomarkersconcussionmilitary blast exposuresubconcussive injuryTraumatic brain injury

Identifiers

PMID36513998
PMCPMC9746108
OpenAlexW4311823573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.