Evidence map›Paper›PMID 36513992›Full record

ArticleBMC nephrology2022

Thrombotic thrombocytopenic purpura developed after pegylated interferon treatment for hepatitis B infection.

Shuqin Mei, Yun Feng, Linlin Cui, Jing Chen, Zhiguo Mao, Xuezhi Zhao, Changlin Mei, Yixin Qian

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shuqin MeiDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Yun FengDepartment of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Linlin CuiDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Jing ChenDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Zhiguo MaoDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Xuezhi ZhaoDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Changlin MeiDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Yixin QianDepartment of Nephrology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China. alexandraqian@163.com.
Fudan University Shanghai Cancer Center · CN

Funding

National Natural Science Foundation of China 81800681National Natural Science Foundation of China 81873595)Shanghai Municipal Key Clinical Specialty shslczdzk02503
6 · The paper itself

Abstract

backgroundThrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ ischemia. It is related to severe deficiency in ADAMTS13, which is usually acquired via ADAMTS13 autoantibodies or inherited via mutations of the ADAMTS13 gene. The etiology of acquired TTP including HIV infection, pregnancy, autoimmune disease, organ transplantation, drugs, malignancy and so on. Here, we firstly reported a patient diagnosed as acquired TTP after pegylated interferon therapy for hepatitis B and COVID-19 vaccination. CASE PRESENTATION: A 36-year-old male attended to our unit with a five-day history of intermittent hematuria and progressive fatigue on January 5th, 2022. He had a 13 years history of hepatitis B infection and undergone pegylated interferon treatment (which was paused for two months because of COVID-19 vaccination) for nearly 3 years. Laboratory evaluation revealed a haemoglobin level of 61 g/L, platelet count of 11 × 10

Indexed as

COVID-19COVID-19 VaccinesHepatitis BHIV InfectionsPurpura, Thrombotic ThrombocytopenicAdultFemaleHumansInterferonsMalePolyethylene GlycolsPregnancyThiamineCOVID-19 VaccinesInterferonsPolyethylene GlycolsThiaminethiamine triphosphorateCOVID-19 vaccinationHepatitis BPegylated interferonThrombotic microangiopathyThrombotic thrombocytopenic purpura

Identifiers

PMID36513992
PMCPMC9745695
OpenAlexW4311361913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.