Evidence map›Paper›PMID 36513746›Full record

ArticleScientific reports2022

Podocyturia: an earlier biomarker of cardiovascular outcomes.

Assaad A Eid, Robert H Habib, Omar Chehab, Nour Al Jalbout, Hani Tamim, Maha Makki, Martine El Bejjani, Joao Lima, Kamal F Badr

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Blood Pressure Management Strategies and Podocyte Health.American journal of hypertension · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Therapeutic potential ofFrontiers in pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Assaad A Eid *Department of Anatomy, Cell Biology and Physiology, American University of Beirut, Beirut, Lebanon.
Robert H Habib *Vascular Medicine Program, Faculty of Medicine, American University of Beirut, Riad El Solh, P.O. Box: 11-0236, Beirut, 1107 2020, Lebanon.
Omar ChehabDepartment of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nour Al JalboutDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hani TamimDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Maha MakkiDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Martine El BejjaniClinical Research Institute, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Joao LimaDepartment of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kamal F BadrVascular Medicine Program, Faculty of Medicine, American University of Beirut, Riad El Solh, P.O. Box: 11-0236, Beirut, 1107 2020, Lebanon. kbadr@aub.edu.lb.
American University of Beirut · LBJohns Hopkins Medicine · USJohns Hopkins University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary podocin and nephrin mRNAs (podocyturia), as candidate biomarkers of endothelial/podocyte injury, were measured by quantitative PCR in Type II diabetics with normal albumin excretion rates (AER) at baseline, at 3-4 years, and at 7 years. Development of cardiovascular disease (CVD) was collected as outcome. Visit 1 podocyturia was significantly higher in subjects who subsequently developed CVD versus those who did not. Visit 1 AER terciles exhibited similar time to CVD, in contrast with stepwise and substantial increases in CVD events predicted by Visit 1 podocyturia terciles. Covariate-adjusted hazard ratios were highest for podocin, intermediate for nephrin mRNAs, and lowest for AER. Podocyturia was also measured in patients with and without significant coronary obstruction, and in 480 normoalbuminuric subjects at the enrolment visit to the Multi-Ethnic Study of Atherosclerosis (MESA). Podocyturia > 3 × 10

Indexed as

AtherosclerosisCardiovascular DiseasesCoronary Artery DiseasePodocytesBiomarkersHumansMaleRisk FactorsBiomarkers

Identifiers

PMID36513746
PMCPMC9747803
OpenAlexW4311305992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.